Hyun Ju Lee MD, Presenter: Nothing to Disclose

Jin Mo Goo MD, PhD, Abstract Co-Author: Nothing to Disclose

Chang Min Park, Abstract Co-Author: Nothing to Disclose

Chang Hyun Lee MD, Abstract Co-Author: Nothing to Disclose

Jung Im Kim MD, Abstract Co-Author: Nothing to Disclose

So Young Choi MD, Abstract Co-Author: Nothing to Disclose

Youkyung Lee MD, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

To evaluate the inter-observer reproducibility of semiautomated volumetic measurement for evaluation of tumor response after chemotherapy in patients with advanced lung cancer

21 patients (M:F=14:7, mean age 62) with advanced lung cancer prospectively underwent 1-mm thick whole-body CT covering from neck to pelvis before and after systemic chemotherapy. Using commercial software (Syngo oncology, Siemens), the volumes of all cancer lesions including lung mass, lymph nodes (LNs), and solid organ metastasis were measured and the volume of whole body lesions were added. Response to treatment after chemotherapy was evaluated by calculation of change in the volume of whole body lesions. The measurement was performed by three readers (reader A, B, and C). Inter-observer measurement reproducibility for evaluation of tumor response was assessed using coefficients of variation (CV).

26 lung masses, 19 LNs, one adrenal mass, and one liver mass were measured. Semiautomated volumetic measurement was feasible in all lesions. The mean number of manual correction for segmentation of lesions from surrounding structures was 1.04 for lung masses, 2.32 for LNs, and 1.32 for solid organ masses. In the evaluation of tumor response in lung masses, the inter-observer averaged CVs between readers A-B, A-C, and B-C were 17.7%, 19.6%, and 23.2%. In LNs, the averaged CVs between readers A-B, A-C, and B-C were 25.1%, 29.1%, and 28.5%. In the evaluation of whole body lesions, the averaged CVs between readers A-B, A-C, and B-C were 20.6%, 23.4%, and 25.8%.

Tumor response evaluation using semiautomated volumetic measurement was feasible. The inter-observer reproducibility was higher in the measurement of lung masses than in the measurement of LNs.

Computer-assisted semiautomated volumetic measurement could be applied to the evaluation of tumor response in patients with advanced lung cancer.

Lee, H, Goo, J, Park, C, Lee, C, Kim, J, Choi, S, Lee, Y, et al, 0, Tumor Response Evaluation in Patients with Advanced Lung Cancer: Measurement Reproducibility of Semiautomated Volumetric Measurement.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8015215.html