Sung Tae Kim MD, Presenter: Nothing to Disclose

In Ho Lee MD, Abstract Co-Author: Nothing to Disclose

Eunhee Kim MD, Abstract Co-Author: Nothing to Disclose

Pyung Jeon MD, Abstract Co-Author: Nothing to Disclose

Keon Ha Kim, Abstract Co-Author: Nothing to Disclose

Hong Sik Byun MD, Abstract Co-Author: Nothing to Disclose

Jung Hee Lee PhD, Abstract Co-Author: Nothing to Disclose

Hyung-Jin Kim MD, Abstract Co-Author: Nothing to Disclose

Ducklyul Na MD, PhD, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

In an attempt to know the region of involvement in cortical neuron and white matter in aMCI, we aimed to map the distribution of FA and MD change using voxel based analysis of diffusion tensor imaging.

Sixty four patients with aMCI , and 73 normal healthy groups underwent diffusion tensor imaging with the parameters of b factor 1000, 45 direction diffusion gradient, and 2.2 mm isovoxel in 3T MRI. Processing of imaging data and voxel-based analysis was performed across the entire brain using tools from SPM5 and FMRIB Software Library. In order to know the difference of FA and MD in aMCI and normal healthy groups, the smoothed FA and MD images for two groups were compared using voxel-wise t-test statistics. Statistical maps of differences in FA and MD between groups were constructed.

Compared to normal healthy controls, aMCI patients showed FA decrease in left hippocampus (p<0.0001, FDR uncorrected). Compared to controls, aMCI patients showed MD increase in both hippocampus, parahippocampal gyrus, inferior basal temporal lobe, insula, and left posterior cingulated gyrus (p< 0.05, FDR corrected).

Our studies suggest that FA is less sensitive than MD in the evaluation of neuronal degeneration of aMCI. And we may conclude that axonal change appears later than neuronal degeneration.

In aMCI, evaluation of MD is more sensitive method than the FA. In aMCI neuronal degeneration precedes white matter changes.    

Kim, S, Lee, I, Kim, E, Jeon, P, Kim, K, Byun, H, Lee, J, Kim, H, Na, D, et al, 0, Voxel-based Analysis of Fractional Anisotropy (FA) and Mean Diffusivity (MD) Change in Amnestic Mild Cognitive Insufficiency (aMCI).  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8014927.html