Johannes Greupner, Presenter: Nothing to Disclose

Elke Zimmermann MD, Abstract Co-Author: Nothing to Disclose

Andrea Grohmann, Abstract Co-Author: Nothing to Disclose

Hans-Peter Dübel MD, Abstract Co-Author: Nothing to Disclose

Bernd K. Hamm MD, Abstract Co-Author: Research Consultant, Bayer AG Research Consultant, Toshiba Corporation Stockholder, Siemens AG Stockholder, General Electric Company Stockholder, Biomed Research grant, Toshiba Corporation Research grant, Koninklijke Philips Electronics NV Research grant, Siemens AG Research grant, General Electric Company Research grant, Elbit Medical Imaging Ltd Research grant, Bayer AG Research grant, Guerbet AG Research grant, Bracco Group Research grant, B. Braun Research grant, Knauth Research grant, Boston Group Equipment support, Elbit Medical Imaging Ltd Investigator, Copenhagen Malmo Contrast AB, Lund, Sweden

Marc Dewey MD, Abstract Co-Author: Research grant, General Electric Company Research grant, Bracco ALTANA Pharma GmbH Research grant, Guerbet SA Research grant, Toshiba Corporation Speakers Bureau, Toshiba Corporation Speakers Bureau, Bayer AG Author, Springer Science+Business Media Deutschland GmbH

To intraindividually compare left ventricular function assessed with multislice computed tomography using 64 simultaneous detector rows (MSCT), biplane cineventriculography (CVG), and both 2D and 3D transthoracic echocardiography (2D and 3D Echo) with magnetic resonance imaging (MRI) as the gold standard as an ancillary single-center study of the multicenter trial “CorE-64”.

A total of 35 patients prospectively underwent MSCT (Aquilion 64, Toshiba Medical Systems, Nasu, Japan), CVG, and MRI, and 2D as well as 3D Echo. All five exams were performed within 24h for each patient. Institutional review board approval for this prospective, cardiac function, ancillary study of a multicenter trial on coronary imaging was obtained.

Regarding the ejection fraction, the agreement was significantly superior for MSCT (±13.6%) than for CVG (±19.8%; P=0.03; F-test) and both 2D Echo (±19.6%; P=0.04; F-test) as well as 3D Echo (±21.6%; P=0.01; F-test). MSCT (57.0 ± 14.9%, P=0.63, t-test), 2D Echo (56.3 ± 14.8%, P=0.88, t-test) and 3D Echo (58.8 ± 16.6%, P=0.26, t-test) did not significantly under- or overestimate ejection fraction in comparison to MRI (56.3 ± 16.2%), whereas CVG (61.1 ± 13.9%, P=0.01, t-test) significantly overestimated ejection fraction. For the stroke volumes, the limits of agreement for CVG (±56.6 ml, P=0.001) and 2D and 3D Echo (±46.0 ml and ±50.1 ml respectively, both P<0.05) were also significantly larger in comparison to MRI than for MSCT (±31.5 ml). In comparison to the reference standard MRI, CVG but not MSCT significantly overestimated the end-diastolic volume (P<0.001). In contrast, both 2D and 3D Echo significantly underestimated the end-diastolic volume (both: P<0.05) in comparison to the reference standard MRI.

64-row computed tomography offers a precise and accurate evaluation of global left ventricular function. Furthermore it appears to be more accurate than CVG, 2D and 3D Echo in comparison to MRI as the  reference standard.

Using the same data sets acquired for non-invasive coronary angiography 64-row CT allows reliable evaluation of global left ventricular function in clinical practice.

Greupner, J, Zimmermann, E, Grohmann, A, Dübel, H, Hamm, B, Dewey, M, Head-to-Head Comparison of Left Ventricular Function Assessment with 64-Row Computed Tomography, Biplane Cineventriculography, and 2D and 3D Transthoracic Echocardiography: A Comparison with Magnetic Resonance Imaging as the Gold Standard.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8014546.html