Aya Kino MD, Presenter: Nothing to Disclose

Sven Zuehlsdorff PhD, Abstract Co-Author: Research grant, Siemens AG

Aoife N. Keeling MD, Abstract Co-Author: Nothing to Disclose

Cormac Thomas Farrelly MD, Abstract Co-Author: Nothing to Disclose

John Sheehan MD, Abstract Co-Author: Nothing to Disclose

James Christopher Carr MD, Abstract Co-Author: Nothing to Disclose

Peter Weale, Abstract Co-Author: Employee, Siemens AG Researcher, Siemens AG

Randall Ramsay, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

The purpose of this study was to compare a navigator gated free breathing 3D Phase Sensitive Inversion Recovery (PSIR) TurboFLASH to an established 2D PSIR TurboFLASH method for detecting myocardial hyperenhanced lesions caused by non-ischemic cardiomyopathy.

Under an IRB approved protocol, 28 patients with suspected infiltrative myocardial heart disease and cardiomyopathy were examined on a 1.5T MR. Delayed images were acquired ten minutes after the administration of contrast agent using a segmented 2D PSIR TurboFLASH sequence followed by a navigator-gated 3D PSIR TurboFLASH sequence. Scar volume were calculated in images from both techniques. Image quality (Likert scale), location and area of the scar were scored by two readers.

28 patients were successfully scanned using both 2D and 3D PSIR techniques. Image quality scores did not differ significantly (p=0.19) for both techniques. Scar were found in 90% of the patients.The total number of hyperenhanced regions detected using 3D PSIR was larger than at 2D PSIR. The quantitative analysis demonstrated that the scar volume were significant higher in 3D PSIR reformatted images than in 2D PSIR (p =0.004).

Free breathing 3D PSIR viability imaging detected more scars than conventional 2D imaging for assessment of infiltrative cardiomyopathies. Preliminary results suggest that the 3D approach may be the method of choice for LGE CMRI in this clinical setting due to its complete isotropic coverage of the LV and improved detection of smaller lesions compared to 2D imaging.

 A 3D PSIR late gadolinium enhancement cardiac MR imaging can assist in differenciate non ischemic cardiomiopaties based on different enhaced patterns due to better coverage and isotropic resolution.

Kino, A, Zuehlsdorff, S, Keeling, A, Farrelly, C, Sheehan, J, Carr, J, Weale, P, Ramsay, R, et al, 0, Three-dimensional Phase Sensitive Inversion Recovery (PSIR) Turbo FLASH for Evaluation of Left Ventricular Myocardial Lesions in Infiltrative and Non-Ischemic Cardiac Diseases  .  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8012650.html