Tony Martin Svahn, Presenter: Nothing to Disclose

Ingvar Tore Andersson MD, PhD, Abstract Co-Author: Nothing to Disclose

Dev Prasad Chakraborty PhD, Abstract Co-Author: Nothing to Disclose

Sune Svensson MS, MS, Abstract Co-Author: Nothing to Disclose

Sophia Zackrisson, Abstract Co-Author: Nothing to Disclose

Debra Masako Ikeda MD, Abstract Co-Author: Research agreement, Hologic, Inc Research grant, Aerospace Research Technologies

Daniel Förnvik MS, Abstract Co-Author: Nothing to Disclose

Pontus Timberg, Abstract Co-Author: Nothing to Disclose

Anders Tingberg, Abstract Co-Author: Nothing to Disclose

Sören Mattsson DSc, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

To compare the diagnostic accuracy of dual-view digital mammography (DM) and single-view breast tomosynthesis (BT) for detection of malignant lesions.

Patients with breasts containing subtle lesions as seen on DM or ultrasonography (US) were selected to undergo BT examination. DM was performed using a Mammomat NovationDR unit (Siemens, Erlangen, Germany), and BT using a prototype device adapted from this unit. The acquisition parameters for the BT and the DM examinations yielded about the same average glandular dose. A DM examination (case) consisted of a mediolateral oblique (MLO) and a craniocaudal view. For BT the MLO view was chosen in the majority (90%) of the cases. Two hundred cases performed with DM and BT was verified by pathology and/or by two-year follow-up by mammography screening, resulting in 92 abnormal and 108 normal/benign cases. Two experienced radiologists, non-participants in the study, outlined the regions of malignancy in the images using the information from US, needle biopsy and pathology. Four expert mammographers interpreted the cases independently in a blinded free-response study. The scored data was analyzed with the jackknife alternative free-response receiver operating characteristic (JAFROC) method.

The JAFROC analysis yielded a statistically significant difference between the modalities (p = 0.00365, F-stat = 8.48). The average figure-of-merits for the observers were 0.847 for BT and 0.785 for dual-view DM.

The results of the study indicate improved diagnostic accuracy using single-view BT compared to dual-view mammography.

The study suggests that BT is superior to DM in the detection of breast cancer. BT permits better outlining of the tumors and should be more accurate in the BIRADS classification and size assessment.

Svahn, T, Andersson, I, Chakraborty, D, Svensson, S, Zackrisson, S, Ikeda, D, Förnvik, D, Timberg, P, Tingberg, A, Mattsson, S, et al, 0, The Diagnostic Accuracy of Breast Tomosynthesis vs Digital Mammography: A Free-Response Observer Performance Study.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8011538.html