Min Soo Park MS, RT, Presenter: Nothing to Disclose

Jung Yul Kim MS, RT, Abstract Co-Author: Nothing to Disclose

Hoon-Hee Park MS, RT, Abstract Co-Author: Nothing to Disclose

Chun Goo Kang MS, RT, Abstract Co-Author: Nothing to Disclose

Jae Sam Kim MS, Abstract Co-Author: Nothing to Disclose

Chang Ho Lee MS, Abstract Co-Author: Nothing to Disclose

Today, Prostate cancer has been gradually increasing, according to the change of internal incidence rate of cancer. Generally, prostate cancer has lead to dead over 90%, in case of metastasis of lymph node and bone. So, innovative development of new radiopharmaceutical and imaging modality is progressed for detection of that metastasis, in nuclear medicine, now. Therefore, this study shows the usefulness of 18F-Fluoride PET/CT improved diagnosability on bone metastasis of prostate cancer.

In this study, 33 male patients with prostate cancer were examined (The mean age: 67.8±10.2 years old). Every patient was done each Whole Body Bone Scan (WBBS) and 18F-Fluoride Positron Emission Tomography/Computed Tomography (18F-Fluoride PET/CT). And then, using Receiver Operating Characteristic Curve (ROC curve), each sensitivity and specificity of two modalities was measured and compared with.

In 22 patients (66.6%) of all, bone metastasis was detected. And, in WBBS, sensitivity was 63.6%, specificity, 81.8%; in 18F-Fluoride PET/CT, sensitivity was 100% and specificity was 90.9%. As a result of ROC curve, AUROC (The Area Under an ROC) of WBBS was 0.778, and that of 18F-Fluoride PET/CT, 0.942.

18F-Fluoride PET/CT was higher both sensitivity and specificity than WBBS, and it was valuable to detect bone metastasis of prostate cancer more definitely, with 3D imaging realization. Also, in 18F-Fluoride PET/CT, physiological images were acquired in more short time than WBBS, so, it was possible to reduce patient’s waiting time and complaint. Therefore, it is considered that 18F-Fluoride PET/CT is able to improve diagnosability by offering more accurate images, as cuts in a share of high cost.

 

Park, M, Kim, J, Park, H, Kang, C, Kim, J, Lee, C, Usefulness of 18F-Fluoride PET/CT in Bone Metastasis of Prostate Cancer  .  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8010285.html