Hyun Jung Yoon MD, Presenter: Nothing to Disclose

Ho-Young Song MD, Abstract Co-Author: Nothing to Disclose

Jin Hyoung Kim MD, Abstract Co-Author: Nothing to Disclose

Hyung Gyu Park, Abstract Co-Author: Nothing to Disclose

Dae-Kee Kim PhD, Abstract Co-Author: Nothing to Disclose

Jung-Hoon Park RT, Abstract Co-Author: Nothing to Disclose

To evaluate the efficacy of an ALK5 inhibitor, IN-1233 for the prevention of neointimal hyperplasia after bare stent placement in a rat common iliac artery model.

In 26 Sprague-Dawley (SD) male rats (300-360 g), a self-expanding metallic bare stent (2 × 6 mm) was inserted into the left common iliac artery with a 22-gauge angiocatheter under fluoroscopic guidance. IN-1233 was daily injected in thirteen rats intraperitonealy for 8 weeks after stent placement (group A) while the other thirteen rats underwent stent placement only (group B). Angiography was performed immediately after stent placement and was repeated at 4 weeks and 8 weeks follow up. Rats were sacrificed 8 weeks after stent placement and histologic findings were obtained. The percentage of neointimal hyperplasia and the intimal/medial area ratio were assessed and compared between the two groups.

Stent placement was technically successful in all rats. During follow-up, inguinal or abdominal herniation of the small bowel occurred in three rats in group A and two of them died. Twenty-four rats completed the experimental protocol. There was no thrombus formation, stent migration, or aneurysmal dilatation of the target segments on follow-up angiography. Percentage of neointimal hyperplasia (26.16 ± 8.75 vs. 45.33 ± 19.09%, P < 0.01) and intimal/medial area ratio (1.93 ± 0.77 vs. 4.99 ± 2.38, P < 0.01) were significantly decreased in group A compared with group B.

IN-1233 is effective for the prevention of neointimal hyperplasia after bare metallic stent placement in a rat common iliac artery model.

The effect of IN-1233 is promising and it is anticipated to prevent or reduce neointimal hyperplasia and stent-related stenosis.  

Yoon, H, Song, H, Kim, J, Park, H, Kim, D, Park, J, An ALK5 Inhibitor, IN-1233: Prevention of Neointimal Hyperplasia after Bare Metallic Stent Placement in a Rat Common Iliac Artery Model.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8010077.html