Valeria Panebianco MD, Presenter: Nothing to Disclose

Valeria Vergari, Abstract Co-Author: Nothing to Disclose

Silvia Bernardo, Abstract Co-Author: Nothing to Disclose

Alessandra Zampelli, Abstract Co-Author: Nothing to Disclose

Carlo De Dominicis, Abstract Co-Author: Nothing to Disclose

Roberto Passariello MD, Abstract Co-Author: Nothing to Disclose

To detect superficial bladder cancer using Dual Source CT cystography and virtual cystoscopy with Cystoscopy Photodynamic diagnosis (PDD) as gold standard.

Twenty-five patients with suspected bladder cancer and ten patients who had undergone transurethral resection of the bladder were studied by CTC and VC in both the supine and prone positions after distending the bladder with air. The patient population was divided into three groups based on lesion size at flexible cystoscopy (group 1: 1–5 mm; group 2: 5.1–9 mm; group 3: >9.1 mm). Results of the CT study were compared with Cystoscopy using Photodynamic diagnosis method (PDD).

Photodynamic diagnosis (PDD) depicted 33 bladder lesion in the 25 patients esaminated while CTC and VC depicted 30 lesions bladder. Sensitivity and specificity values of CTC and VC alone were constantly lower than those of the combined-approach (group 1: 95.10% and 94.31%; group 2: 100% and 100%; group 3: 100% and 100%, respectively). Receiver operating characteristic (ROC) curve analysis showed that the combined approach decreases the lower dimensional threshold for lesion detection (1.4 mm).

Dual-Source CT cystography (CTC) and virtual cystoscopy (VC) are promising diagnostic techniques for identification of superficial small size bladder cancer (1–5 mm). Further studies on larger patient populations are required to validate our results.

CT cistography and virtual cystoscopy can be use to early detection of bladder lesions using Dual Source technique

Panebianco, V, Vergari, V, Bernardo, S, Zampelli, A, De Dominicis, C, Passariello, R, Dual Source CT Cystography and Virtual Cystoscopy in the Diagnosis of Superficial Bladder Cancer: Preliminary Experience Using Cystoscopy with Photodynamic Diagnosis (PDD) as Gold Standard.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8006754.html