Minjie Lu, Abstract Co-Author: Nothing to Disclose

Shihua Zhao MD, Abstract Co-Author: Nothing to Disclose

Shiliang Jiang MD, Abstract Co-Author: Nothing to Disclose

Yuqing Liu, Abstract Co-Author: Nothing to Disclose

Renate Jerecic PhD, Presenter: Employee, Siemens AG

To assess the clinical application value of time-adaptive sensitivity encoding (TSENSE) with single breath hold true fast imaging with steady-state precession (truefisp) cine sequences for the left ventricular function in comparion with GeneRalized autocalibrating partially parallel acquisitions (GRAPPA) multi-breath hold truefisp cine sequences.

30 healthy adult volunteers (male 21, female 9, age 48.23±10.58y ) and 32 with cardiac disease (male 28, female 4, age 49.03±15.21y) were studied for evaluating left ventricular function with use of multi-breath hold GRAPPA and single breath hold TSENSE truefisp left ventricular short axis cine. The ventricular function parameters including ejection fraction (EF), end diastolic volume (EDV) end systolic volume (ESV), stroke volume (SV), cardiac output (CO), mean myocardial mass(MM) and heart rate (HR) were calculated by using analysis software (Argus, Simens) after drawing the contour of endocardium and epicedium on TSENSE and GRAPPA cines. A paired-samples t test was used to analyze the difference. P＜0.05 is considered significant difference.

In volunteers group, TSENSE technique leads to a decrease of 0.172 L/min (t=2.262, P=0.03) in CO comparing with GRAPPA technique. There was no significant difference for EF(58.87% vs. 59.43%, t=1.060, P=0.298), EDV（99.11ml vs. 102.67ml, t=1.899, P=0.068,）, ESV(41.14ml vs. 42.28ml, t=1.186, P=0.245), SV（57.91ml vs. 60.33ml, t=1.966, P=0.059）and MM(102.09g vs. 100.36g, t=-1.236, P=0.226). In patients group, there was no significant difference for all ventricular functional parameters including EF (50.33% vs. 50.58%, t=0.778, P=0.442)，EDV（127.78ml vs. 130.20ml, t=1.448, P= P=0.158,），ESV(68.41ml vs. 68.81ml, t=0.488, P=0.629)，SV(59.29ml vs. 61.40ml, t=1.837, P=0.076) ，CO（4.17L/min vs. 4.28L/min, t=1.350, P=0.187）and MM(126.55g vs. 132.59g, t=2.262, P=0.091).

Compared with multi-breath hold GRAPPA technique, single breath hold TSENSE technique is a fast, accurate and reproducible method and can be an substitute for GRAPPA to evaluate ventricular function.

TSENSE cine is a robust technique and can be an alternative method for cardiac function analysis,especially for patients with poor breathhold ability.

Lu, M, Zhao, S, Jiang, S, Liu, Y, Jerecic, R, Cardiac Functional Analysis with Time Adaptive Sensitivity Encoding (TSENSE) Technique: Comparison with Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) Technique.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8005861.html