Shunya Sunami, Presenter: Nothing to Disclose

Hidetake Yabuuchi MD, Abstract Co-Author: Nothing to Disclose

Takeshi Kamitani MD, Abstract Co-Author: Nothing to Disclose

Taro Setoguchi MD, Abstract Co-Author: Nothing to Disclose

Shuji Sakai MD, PhD, Abstract Co-Author: Nothing to Disclose

Shinji Ohno MD,PhD, Abstract Co-Author: Nothing to Disclose

Kenichi Nishiyama MD,PhD, Abstract Co-Author: Nothing to Disclose

Toshiro Kuroiwa, Abstract Co-Author: Nothing to Disclose

Mikako Jinnouchi, Abstract Co-Author: Nothing to Disclose

Masato Yonezawa, Abstract Co-Author: Nothing to Disclose

Masamitsu Hatakenaka MD, PhD, Abstract Co-Author: Nothing to Disclose

Hiroshi Honda MD, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

To evaluate the correlation between MR imaging findings and receptor status of invasive breast cancers with three different receptor status (hormone receptor negative/her2 negative “triple negative”, TN; hormone receptor negative/her2 overexpression, HER2; , hormone receptor positive/her2 negative, HR)

Two hundred and seventeen pathologically proven invasive breast cancers with three receptor statuses (TN, HER2 and HR tumors) in 210 women (mean age 58 years; range 28-86 years) were reviewed by two experienced breast radiologists in consensus fashion. Primary MR features were coded as mass lesion, non-mass lesion,　and mass with non-mass lesion. Subsequently, we assessed following MR imaging findings using BI-RADS MRI lexicon; mass shape, margin, internal enhancement, size, distribution of non-mass lesion, kinetic curve assessment. We also assessed apparent diffusion coefficient (ADC) value of mass lesions. The MR findings and receptor status were statistically analyzed to determine whether any correlations existed.

Forty-three TN, 29 HER2 and 145 HR tumors were assessed. Primary MR features were not significantly different among three groups, however, non-mass lesion with segmental distribution was significantly associated with HER2 (16/19) than TN (9/22) tumors (P=0.009). Mean maximal diameter of TN tumors was significantly larger than that of HR tumors (mean ± SD: 25.1±15.4 vs.17.2 ± 8.5mm, p=0.0039). Smooth mass margin was more common in TN (9/39) than HR (6/123) tumors, and spiculated margin was more common HR (42/123) than TN (4/39) tumors, whereas no significant difference was observed between TN and HER2 tumors and between HER2 and HR tumors. Internal enhancement, kinetic feature and ADC value of mass lesion were not significantly different among three groups.

Receptor status of invasive breast cancer might reflect to several MR imaging findings.

Recognition of several MR imaging features which correlated with receptor status might help to decide the treatment plan.

Sunami, S, Yabuuchi, H, Kamitani, T, Setoguchi, T, Sakai, S, Ohno, S, Nishiyama, K, Kuroiwa, T, Jinnouchi, M, Yonezawa, M, Hatakenaka, M, Honda, H, et al, 0, MR Imaging Features of Invasive Breast Cancers with Three Distinctive Receptor Statuses (Hormone Receptor Negative/HER2 Negative “Triple Negative”, Hormone Receptor Negative/HER2 Overexpression, Hormone Receptor Positive/HER2 Negative).  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8004512.html