Bing Yu MD, Presenter: Nothing to Disclose

Guoguang Fan PhD, Abstract Co-Author: Nothing to Disclose

Na Liu MD, Abstract Co-Author: Nothing to Disclose

Qiyong Guo MD, Abstract Co-Author: Nothing to Disclose

To compare  target controlled with manually controlled infusion of propfol in the incidence of adverse respiratory events, the need for airway interventions, and the recovery time after sedation for sedation of patients who were difficult to sedative with oral pentobarbital or oral chloral hydrate.

This study was conducted with institutional review board approval and parental informed consent. Between May 2007 and December 2008, parents whose child could not be sedated with oral pentobarbital or oral chloral hydrate were given the choice of having their child sedated with intravenously target controlled infusion(TCI) or manually controlled infusion (MCI) of propofol during pediatric diagnostic CT. 166 patients (75 female, 91male; mean age, 4.1± 1.8 years ) received target controlled infusion of propofol ,166 patients (89 female, 77 male; mean age, 3.9 ± 2.1 years) received manually controlled infusion of propofol. All sedatives were administered by a radiology nurse under the supervision of an anesthesiologist. The doses of propofol, the airway manipulations, adverse respiratory events, and recovery time after sedation were measured between the groups by using the Fisher exact test and the u test. A two-tailed P value of less than 0.05 indicated a significant difference between groups.

Patients sedated with TCI of propofol required lower doses of propofol (P<0.05). Patients sedated with TCI of propofol during induction underwent significantly less airway manipulations to relieve obstruction than did patients sedated with MCI (5.4% vs 21.1%, P <0.05). Less adverse respiratory events occurred in the TCI group than in the MCI group (3.6% vs 13.9%, P <0.05). Patients in the TCI group had a faster recovery profile than did patients in the MCI group (25 minutes±17 vs 40 minutes±16, P <0.05).

Target controlled infusion of propofol is associated with a significantly lesser incidence of adverse respiratory events than manually infusion for sedation of difficult-to-sedative patients during pediatric diagnostic CT.

Target controlled infusion of propofol is safer than manually infusion for sedation of difficult-to-sedative patients during pediatric diagnostic CT.

Yu, B, Fan, G, Liu, N, Guo, Q, Is Target Controlled Infusion of Propofol Safer for Sedation of Difficult to Sedative Patients during Pediatric Diagnostic CT?.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8003493.html