Takeshi Kamitani MD, Presenter: Nothing to Disclose

Hidetake Yabuuchi MD, Abstract Co-Author: Nothing to Disclose

Shunya Sunami MD, Abstract Co-Author: Nothing to Disclose

Taro Setoguchi MD, Abstract Co-Author: Nothing to Disclose

Mikako Jinnouchi, Abstract Co-Author: Nothing to Disclose

Masato Yonezawa, Abstract Co-Author: Nothing to Disclose

Shuji Sakai MD, PhD, Abstract Co-Author: Nothing to Disclose

Masamitsu Hatakenaka MD, PhD, Abstract Co-Author: Nothing to Disclose

Nobuhiro Fujita MD, Abstract Co-Author: Nothing to Disclose

Hiroshi Honda MD, Abstract Co-Author: Nothing to Disclose

00030490-DMT et al, Abstract Co-Author: Nothing to Disclose

To evaluate the usefulness of diffusion-weighted MR imaging (DWI) of breast cancer for predicting axillary node status, nuclear grade, estrogen receptor (ER) status, progesterone receptor (PgR) status, and human epidermal growth factor receptor type 2 (HER2) status.

Eighty-six patients who underwent breast MRI and were diagnosed pathologically as having invasive ductal carcinoma not otherwise specified with invasive foci 1cm or larger were enrolled in this study. Non-invasive carcinoma and invasive ductal carcinoma with invasive foci smaller than 1cm were excluded because small lesions decrease the reliability of the signal intensity of DWI. Special-type cancers were also excluded. The apparent diffusion coefficient (ADC) of breast cancer was calculated using two b factors (0 and 1000 s/mm2). Mean ADCs were compared between cancers with and without lymph node metastasis, with and without ER, and with and without PgR, respectively, by unpaired t-test. Spearman correlation coefficients were used to evaluate whether ADC was correlated with nuclear grade and extent of HER2 expression.

The mean ADC of node-positive breast cancers (n=31) was significantly greater than that of node-negative cancer (n=55) (1.06±0.25×10-3mm2/s vs. 0.93±0.16×10-3mm2/s) (P=0.01). The mean ADC of ER positive cancers (n=67) was significantly smaller than that of ER negative cancers (n=19) (0.94±0.19×10-3mm2/s vs. 1.08±0.24×10-3mm2/s) (P=0.009). On the other hand, PgR status, nuclear grade, and HER2 status showed no statistically significant correlation with ADC.

Node-positive and ER-negative breast cancers showed higher ADCs than node-negative and ER-positive cancers, respectively. PgR status, nuclear grade, and HER2 status showed no statistically significant correlation with ADC.

DWI can help to predict axillary lymph node status and ER status of breast cancer.

Kamitani, T, Yabuuchi, H, Sunami, S, Setoguchi, T, Jinnouchi, M, Yonezawa, M, Sakai, S, Hatakenaka, M, Fujita, N, Honda, H, et al, 0, ADC of Breast Cancer: Correlation with Axillary Lymph Node Status, Nuclear Grade, Hormone Receptor Status, and HER2 Status.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8003208.html