Takeshi Hayashida MD, Presenter: Nothing to Disclose

Eijun Sueyoshi MD, Abstract Co-Author: Nothing to Disclose

Ichiro Sakamoto, Abstract Co-Author: Nothing to Disclose

Masataka Uetani MD, Abstract Co-Author: Nothing to Disclose

The Indine-123-metaionidobenzylguanidine Scintigram and cardiac contrast enhanced magnetic resonance imaging are useful methods for identification of myocardial dysfunction. Recently, several reports have highlighted the potential role of delayed enhancement (DE) cardiac MR imaging for the assessment of patients with dilated cardiomyopathy (DCM). The purpose of this study was to compare the 123I-MIBG scintigram with DE cardiac MR imaging for detection of myocardial dysfunction in patients with DCM.

DCM patients (n=29: mean age, 51.9years; seven women) were evaluated by both DE cardiac MR imaging and 123I-MIBG scintigram. The heart-to-mediastinum radioactivity ratio (H/M ratio), washout rate (WR) and average CNR per slice (aCNR) for the LV myocardium were evaluated. 123I-MIBG scintigram was acquired at 3 hours (delayed imaging) after intravenous administration of 123I-MIBG (111MBq). Delayed H/M ratio and WR was calculated. DE cardiac MR images were acquired using a two-dimensional segmented inversion-recovery prepared gradient-echo sequence (TI=250msec) 15minutes after intravenous administration of 0.1 mmol/kg gadolinium. We evaluated the relationships between delayed H/M ratio, WR, aCNR and New York Heart Association (NYHA).

In 123I-MIBG scintigram, WR was significantly higher in the NYHA III-IV (41.7±12.1) groups (n=21) than in the NYHA I-II (27.7±14.7) groups (n=8). However, aCNR and delayed H/M ratio were not significantly different between the NYHA III-IV (aCNR; 4.3±4.1, delayed H/M ratio;1.7±0,2)groups and the NYHA I-II (aCNR; 3.4±3.0, delayed H/M ratio;1.8±0.3) groups.

123I-MIBG scintigram reflects the NYHA in patients with DCM, which may be related with the myocardial dysfunction. 123I-MIBG scintigram may be more useful to evaluate the myocardial dysfunction than DE cardiac MR images.

In Indine-123-metaionidobenzylguanidine (123I-MIBG) scintigram, washout rate in patients with dilated cardiomyopathy has been considered to accurately assess the myocardial dysfunction.

Hayashida, T, Sueyoshi, E, Sakamoto, I, Uetani, M, Comparison of Indine-123-metaionidobenzylguanidine Scintigram with Contrast-enhanced MR Imaging for Detection of Myocardial Damage in Patients with Dilated Cardiomyopathy.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8002445.html