Soenke Langner MD, Presenter: Nothing to Disclose

Martin Domin, Abstract Co-Author: Nothing to Disclose

Norbert Hosten MD, Abstract Co-Author: Nothing to Disclose

Michael Kirsch MD, Abstract Co-Author: Nothing to Disclose

The goal of this study was to characterize the diffusion parameters of the healthy human spinal cord in vivo. This data is essential for the characterization and comparison of pathologic conditions. It can also be used to compare different pulse sequences for Diffusion Tensor Imaging (DTI).

A total of 25 healthy subjects with no neurological disorders and no recent history (within the last 6 months) of back pain were enclosed. We used an axial single-shot GRE-EPI-sequenz with ECG-trigger on every second pulse. Other imaging parameters included TE 86ms, TR 3000ms slice thickness 3mm, Number of averages 1, FOV 140mm, in-plane resolution 2.2x2.2x3mm and b-values of 0 and 700. Acquisition time for each slice was 1.29min. We acquired axial slices from the level of the cranio-cervical junction to the level of vertebral L2/3. Mean diffusivity (MD) and fractional anisotropy (FA) were calculated with an in-house developed software and color-coded parameter maps were calculated. Diffusion parameters were evaluated by placing a region-of-interest (ROI) within the whole diameter of the myelon.

In 25 volunteers a total of 328 diffusion weighted images were acquired. There were slight geometric distorsions, especially in the upper cervical spine. However, cerebrospinal fluid (CSF) and spinal cord as well as gray and white matter contrast were observed in all slices. Fractional anisotropy averaged 0.46 ±0.06 x10-3 mm2/s and MD averaged 0.69 ± 0.05 x10-3 mm2/s.

This study provides normal diffusion parameters of the healthy human spinal cord in vivo. This data can be used for the comparison of different pathologic conditions of the cord or to compare and improve pulse sequences used for DTI.

This study provides normal diffusion parameters of the healthy human spinal cord in vivo.

Langner, S, Domin, M, Hosten, N, Kirsch, M, Diffusion Tensor Imaging of the Healthy Human Spinal Cord.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8000412.html