Ahmed Abdel Razek, Presenter: Nothing to Disclose

Ahmed Abdalla, Abstract Co-Author: Nothing to Disclose

Nahid Abdel Gaber, Abstract Co-Author: Nothing to Disclose

Abeer Fathy, Abstract Co-Author: Nothing to Disclose

To correlates the apparent diffusion coefficient (ADC) value of vertebral bone marrow in patients with Gaucher’s disease with genotyping.

Twenty two patients (14M, 8F aged 3-14ys: mean 6.5ys) with Gaucher’s disease underwent diffusion weighted MR imaging and quantitative chemical shift imaging (QCSI) of the lumbar spine. A total of 22 aged matched volunteers underwent the same MR study. Diffusion MR weighted imaging was done on 1.5 tesla unit (Symphony, Siemens) using a single shot spin echo type of echo planar imaging. The parameters used were TR/TE: 4200/38 msec, B value = 0, 500 & 1000 sec/mm2. The ADC map was reconstructed. The ADC value and fat fraction ratio of the lumbar vertebral bodies was calculated. The ADC value correlated with fat fraction ratio and genotying.

The mean ADC value of cellular bone marrow in volunteers was 0.68±0.13 X 10-3 mm2/sec. The mean ADC value of marrow infiltration in Gaucher’s patients was 0.47±0.11 X 10-3 mm2/sec. There was statistically significant difference in the ADC value between cellular marrow of normal volunteers and marrow infiltration in patients with Gaucher’s disease (P<0.001). The mean ADC value of bone marrow correlated with fat fraction ratio (r=0.91). The N370S compound heterozygous had significantly lower ADC value compared to N370S homozygous (P<0.003).

We concluded that apparent diffusion coefficient value is a new promising quantitative imaging parameter for detection of vertebral bone marrow infiltration in pediatric patients with Gaucher’s disease and correlated with genotyping.

The apparent coefficient value is a new parameter that can be used to asses vertebral bone marrow infiltration in pediatric with Gaucher’s disease and correlated with genotyping.

Abdel Razek, A, Abdalla, A, Abdel Gaber, N, Fathy, A, Gaucher’s Disease: Correlation of Apparent Diffusion Coefficient Value of Vertebral Bone Marrow with Genotyping.  Radiological Society of North America 2009 Scientific Assembly and Annual Meeting, November 29 - December 4, 2009 ,Chicago IL. http://archive.rsna.org/2009/8000164.html