Ernesto Roldan-Valadez MD, Presenter: Nothing to Disclose

Cecilia Elizabeth Perez Mendieta MD, Abstract Co-Author: Nothing to Disclose

Ingrid Vivas-Bonilla MD, Abstract Co-Author: Nothing to Disclose

Manuel Martinez-Lopez MD, Abstract Co-Author: Nothing to Disclose

Jorge Vazquez-Lamadrid MD, Abstract Co-Author: Nothing to Disclose

The mesial sclerosis of hippocampus (MSH) is cause of the temporal lobe epilepsy (ELT) in 70% of the cases, it presents in magnetic resonance (MR) as hiperintensity and atrophies of the seahorse.

In progress study at the Foundation clinical “Medica Sur” . Have been studied 35 brain RM during July 1 to the one March 31 the 2008 (20 patients and 15 controls) whit sequences FLAIR (hiperintensity) and T2 (volume). The spectroscopy univoxel obtained the index of N-acetyl aspartate divided by the Creatine sum but Choline (NAA/ (Cho+Cr)) in both hippocampi and were identified the primary and secondary discovery associated to MSH.

The age average was 28.89 years, (range 16-58). In the group control, the volume of the smallest hippocampus was 2.50 ± 0.28 cm3 with asymmetry volumetric index (AVI) of 7.57%. In those patients with ELT, the volume of the smallest hippocampus was 2.05 ± 0.57cm3 with IVA of 31.51%. The comparison of the AVI was significant (p <0.05). The index NAA/Cho+Cr of the sick hippocampus in the group of patients he/she had an average of 0.65. The primary discoveries they were present in 85-90% and the secondary ones in 30-60%.

The patients with TLE, have a bigger IVA to the one 10% and an index of smaller NAA/Cho+Cr at 0.71. The volumetric and spectroscopic hippocampuses is essential when studying the TLE. The asymmetry in volumetric index suggests a chronic and progressive evolution of the MSH. The primary discoveries are the first point to evaluate. Those secondary changes indicate the extension of the included MHS they can identify focuses of epilepsy even in thecontralateral temporal lobe.

The integral evaluation of hippocampus can help clinicians to discover the disease in the initial stages before fingdings in conventional MRI, this support evidence for early treatment.

Roldan-Valadez, E, Perez Mendieta, C, Vivas-Bonilla, I, Martinez-Lopez, M, Vazquez-Lamadrid, J, Integral Evaluation of Hippocampus with Spectroscopy and Volumetry in Patients with Temporal Lobe Epilepsy Using 3.0 T MRI.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6021443.html