Ozgur Kilickesmez MD, Presenter: Nothing to Disclose

Sibel Bayramoglu MD, Abstract Co-Author: Nothing to Disclose

Ercan Inci MD, Abstract Co-Author: Nothing to Disclose

Tan Cimilli MD, Abstract Co-Author: Nothing to Disclose

Neslihan Tasdelen MD, Abstract Co-Author: Nothing to Disclose

Mutlu Cihangiroglu MD, Abstract Co-Author: Nothing to Disclose

Nevzat Gurmen MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To determine apparent diffusion coefficient (ADC) values of normal uterine zones and to evaluate the diagnostic accuracy of ADC measurement for discrimination of malignant from benign uterine lesions.  

A total of 87 patients (mean age, 53) with 107 benign and malignant uterine pathologies and 50 healthy controls (mean age, 38) were enrolled in the study. DW MRI was performed with b factors of 0, 500 and 1000 s/mm². ADC values of the lesions were calculated.  

We compared ADC values between malignant and benign lesions using Student’s t-test. The mean and standard deviation of ADC values of the control group were as follows: myometrium (1.76 ± 0.19 x10ˉ³ mm²/s), junctional zone (0.99 ± 0.18 x10ˉ³ mm²/s), endometrium (1.65 ± 0.33 x10ˉ³ mm²/s), and cervix were (1.71 ± 0.17 x10ˉ³ mm²/s). There was statistically significant difference among the ADC values of normal myometrium and leiomyomas (1.47±0.36,11 x10ˉ³ mm²/s), (p<0.009), endometrium and endometrial carcinomas (0.86±0.13x10ˉ³ mm²/s), (p<0.001), junctional zone-myometrium and adenomyosis (1.24± 0.20 x10ˉ³mm²/s), (p<0.001), cervix and cervical carcinomas (0.91±0.14x10ˉ³ mm²/s), (p<0.001). The ADC values differed significantly between malignant (0.88±0.11) and benign lesions (1.55±0.33) (p<0.01). The cutoff value for malignant lesions at 1.05×10ˉ³ mm²/s yielded a sensitivity, and specificity of 95.83%, 94.55% respectively.  

The present study showed, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue of the uterine zones. We propose to add the DW sequence in the MR protocol for simple determination of uterine malignancies.  

We have planned this study to determine if the use of DWI alone could be able to detect malignant uterine diseases. The results were positive.

Kilickesmez, O, Bayramoglu, S, Inci, E, Cimilli, T, Tasdelen, N, Cihangiroglu, M, Gurmen, N, et al, , Quantitative DWI of the Uterine Diseases.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6017818.html