Govind Babusing Chavhan MD, Presenter: Nothing to Disclose

Paul S. Babyn MD, Abstract Co-Author: Nothing to Disclose

Bejoy Thomas MBBS, MD, Abstract Co-Author: Nothing to Disclose

Manohar Meghraj Shroff MD, Abstract Co-Author: Nothing to Disclose

E. Mark Haacke PhD, Abstract Co-Author: Researcher, Siemens AG

1. To discuss basic physics of T2* relaxation and differences with T2 relaxation. 2. To discuss T2* based MR sequences and illustrate their clinical applications in neuro and body imaging. 3. To discuss principles of T2* contrast based MR applications such as perfusion and functional MR imaging.

@ What is T2* relaxation? @ Characteristics of T2* based contrast @ Various T2*-weighted gradient echo (GRE) sequences principles, trade names and clinical applications @ T2* contrast based special MR applications- MR perfusion, Blood oxygen level dependant (BOLD) imaging, Susceptibility weighted imaging, and Iron overload imaging @ Summary

T2* relaxation, seen in GRE sequences, is decay of transverse magnetization caused by combination of spin-spin relaxation and magnetic field inhomogeneity. Increase in T2* enhances the susceptibility effects and leads to reduction in signal. GRE sequences with T2* based contrast are used to detect hemorrhage, calcification, iron deposition in various tissues and lesions. T2* based contrast forms the basis for advanced applications such as MR perfusion, functional MRI and iron overload imaging.

Chavhan, G, Babyn, P, Thomas, B, Shroff, M, Haacke, E, T2* (T2 star)-based MR Imaging: Principles and Clinical Applications.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6015060.html