Rachel Frydman Brem MD, Abstract Co-Author: Board of Directors, iCAD, Inc Consultant, iCAD, Inc Stockholder, iCAD, Inc Stock options, iCAD, Inc Board Member, Dilon Technologies LLC Consultant, Orbotech Ltd

Marina Ioffe MD, Abstract Co-Author: Consultant, Dilon Technologies LLC

Jocelyn A Rapeyea MD, Presenter: Nothing to Disclose

Jean M. Weigert MD, Abstract Co-Author: Research grant, Dilon Technologies LLC

Margaret Lins Bertrand MD, Abstract Co-Author: Speakers Bureau, Dilon Technologies LLC Speaker, C. R. Bard, Inc

Lillian Hirsch Stern MD, Abstract Co-Author: Speakers Bureau, Dilon Technologies LLC

To compare the sensitivity of mammography, ultrasound, magnetic resonance imaging, and breast-specific gamma imaging in the detection of invasive lobular carcinoma.

This is a retrospective multi-center study of women with biopsy-proven pure ILC. Patients had imaging with mammography and BSGI. US and MRI results, if performed, and pathologic tumor size were included. Each study was classified as positive or negative by experienced breast imagers. The sensitivity of mammography, US, MRI, and BSGI was determined for each modality and compared

Twenty six women ages 46 to 82 (mean age 62.8) with 28 biopsy proven pure ILC, mean size of 22.3mm (2mm-90mm) were included. Mammograms were negative in 6/28 (21%) cancers. Abnormal mammographic findings, 22/28 in total, included 13 asymmetric densities, 4 architectural distortions, and 5 spiculated masses. Mammography had a sensitivity of 79%. In the 25 patients who underwent US, 17 focal hypoechoic areas were detected. Sensitivity of US was 68%. Twelve patients had MRI with 10/12 lesions showing enhancement. Sensitivity of MRI was 83%. BSGI demonstrated increased uptake in 26/28 cases with a sensitivity of 93%.

BSGI has the greatest sensitivity for the detection of ILC with a sensitivity of 93% while mammography, US, and MRI demonstrated sensitivities of 79%, 68% and 83%, respectively. With its high sensitivity for detecting ILC, BSGI is an effective modality that should be used to evaluate patients with suspected cancer and has a promising role in the diagnosis of ILC.

BSGI is a highly sensitive imaging modality for the diagnois of invasive  lobular carcinoma.

Brem, R, Ioffe, M, Rapeyea, J, Weigert, J, Bertrand, M, Stern, L, Invasive Lobular Carcinoma: Detection with Mammography, Ultrasound, Magnetic Resonance Imaging, and Breast-specific Gamma Imaging (BSGI).  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6014637.html