Tobias Franiel MD, Presenter: Nothing to Disclose

Lutz Luedemann PhD, Abstract Co-Author: Nothing to Disclose

Birgit Rudolph, Abstract Co-Author: Nothing to Disclose

Matthias Taupitz MD, PhD, Abstract Co-Author: Nothing to Disclose

Bernd K. Hamm MD, Abstract Co-Author: Nothing to Disclose

Dirk Beyersdorff MD, Abstract Co-Author: Nothing to Disclose

To determine and quantify MRI parameters that allow calculation of histological mean vessel density (MVD), mean vessel area (MVA), and mean interstitial area (MIA).

Thirty-eight consecutive patients with biopsy-proven prostate cancer (PSA: 1.4-31.4ng/ml) were examined with a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence (temporal resolution, 1.65s) at 1.5 Tesla using the combined endorectal/body phased-array coil to calculate blood volume, interstitial volume, and perfusion. In 35 patients who underwent prostatectomy, blood and interstitial volumes and perfusion were correlated with MVD, MVA, and MIA in 95 areas (36x prostate cancer, 27x chronic prostatitis, 32x normal prostate tissue) in immunohistochemically prepared histologic sections corresponding to the MR images. For each MRI area, 5 1mm2 squares (100x magnification) of the matching histologic area were analyzed.

Blood volume correlated adequately with MVD (RS=0.252, p=0.014) but not with MVA (p=0.759). Interstitial volume did not correlate with MIA (p=0.507). Blood volume differed significantly between prostate cancer and normal prostate (1.49 vs. 0.84%, p<0.001) and interstitial volume between chronic prostatitis and normal prostate (39.00% vs. 22.59%, p=0.022). Perfusion differed significantly between prostate cancer and normal prostate (0.97 vs. 0.34ml/cm3*min, p<0.001), between prostate cancer and chronic prostatitis (0.97 vs. 0.60ml/cm3*min, p=0.026), and between chronic prostatitis and normal prostate (0.60 vs. 0.34ml/cm3*min, p=0.023).

The pharmacokinetic parameters blood volume and interstitial volume did not reliably correlate with the histological parameters of MVD, MVA, and MIA. Only the pharmacokinetic inflow parameter, perfusion, enabled significant separation of prostate cancer, chronic prostatitis, and normal prostate.

The pharmacokinetic inflow parameter, perfusion, enabled significant separation of prostate cancer, chronic prostatitis, and normal prostate.

Franiel, T, Luedemann, L, Rudolph, B, Taupitz, M, Hamm, B, Beyersdorff, D, Prostate MRI: Tissue Characterization Using Pharmacokinetic Volume and Perfusion Parameters and Correlation with the Histologic Prognostic Factor Mean Vessel Density, Histologic Mean Vessel Area, and Mean Interstitial Area.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6014413.html