Eun-Ah Park MD, Presenter: Nothing to Disclose

Hyun Ju Lee MD, Abstract Co-Author: Nothing to Disclose

Jin Mo Goo MD, PhD, Abstract Co-Author: Nothing to Disclose

Chang Hyun Lee MD, Abstract Co-Author: Nothing to Disclose

Chang Min Park, Abstract Co-Author: Nothing to Disclose

Jung-Gi Im MD, Abstract Co-Author: Nothing to Disclose

Ho Yun Lee MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To identify the CT, FDG-PET, and histopathology factors correlated with EGFR gene copy number status in surgically resected lung adenocarcinoma

: Institutional review board approval and the requirement for informed consent were obtained. In 132 patients who underwent surgical resection of lung adenocarcinoma (M:F= 59:73; mean age, 61 years), EGFR gene copy number status was categorized into FISH-positive or -negative. Tumor characteristics on preoperative chest-CT, such as, GGO proportions, tumor diameters, and the presences of bubble-like lucency, air-bronchogram, cavitation , spiculated margin, lobulated border, or calcification; FDG-PET SUVmax; and histopathologically determined differentiation degrees and tumor subtypes were retrospectively evaluated. The relationship between EGFR gene copy number status and CT, FDG-PET, and histopathology were evaluated using Fisher’s exact test, Student-t test, Chi-square test for trend, and logistic regression analysis.

FISH-positivity was found in 53 (40.2%) and was significantly more frequent in tumors with a SUVmax>7.0 (P=0.007). Furthermore, FISH-negativity was more frequent in tumors with a GGO>50% (P = 0.023), a bubble-like lucency (P=0.027), and diameter<15.5 mm (P=0.006) on CT, or a well-differentiated histopathology (P=0.002). Moreover, FISH-positivity frequencies increased as SUVmax increased (P = 0.0008) and as the proportion of GGO decreased (P = 0.01). SUVmax>7.0 was an independent predictor of FISH-positive results (Odds ratio, 3.941; 95% CI, 1.691-9.182; P=0.01).

A high SUVmax on FDG-PET was significantly related to a FISH-positive result. Bubble-like lucency, a high proportion of GGO, small tumor diameter on CT, and a well-differentiated histopathology were more frequent in FISH-negative adenocarcinomas.

Low EGFR gene copy number in lung adenocarcinoma is correlated with well-known good prognostic factors such as low SUVmax on PET, well-differentiated pathology, and high proportion of GGO on CT.

Park, E, Lee, H, Goo, J, Lee, C, Park, C, Im, J, Lee, H, et al, , EGFR Gene Copy Number in Adenocarcinoma of the Lung by FISH Analysis: Investigation of Significantly Related Factors on CT, FDG-PET, and Histopathology.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6011457.html