Ashley McAllister Groves MBBS, Abstract Co-Author: Nothing to Disclose

Leon Jonathan Menezes FRCR, Presenter: Nothing to Disclose

Thida Win, Abstract Co-Author: Nothing to Disclose

Nicholas J. Screaton BMBCh, Abstract Co-Author: Nothing to Disclose

Marko Nicholas Berovic MBBS, FRCR, Abstract Co-Author: Nothing to Disclose

Raymondo Endozo, Abstract Co-Author: Nothing to Disclose

Helen Booth, Abstract Co-Author: Nothing to Disclose

John Dickson PhD, Abstract Co-Author: Nothing to Disclose

Irfan Akbar Kayani MBBS, Abstract Co-Author: Nothing to Disclose

Peter Josef Ell MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To perform a prospective and first evaluation of integrated PET/CT in patients with DILD in order to investigate possible pulmonary metabolic and inflammatory processes involved.

Twenty-eight consecutive patients (23-male, 5-female, mean-age 68.3±10.2 years) with DILD were recruited for PET/CT and HRCT. Fused PET and HRCT images were used to define lung parenchymal patterns at sites of maximum 18F-FDG metabolism.

There was raised pulmonary 18F-FDG metabolism in 28/28 patients. At the site of maximal 18F-FDG uptake, the corresponding lung parenchymal pattern on HRCT was predominantly inflammatory in 6/28 and fibrotic/mixed in 22/28. The mean 18F-FDG value (SUVmax) in patients with inflammatory predominance was 2.1±0.4, while in those with a fibrotic or mixed predominance it was 3.1±1.1 (t-test, p=0.045). There was increased mediastinal lymph-node 18F-FDG metabolism in 25/28 patients.

There is increased (Glut-1-mediated) glucose metabolism in both the inflammatory and the fibrotic HRCT lung changes in DILD. The metabolism was higher in the fibrotic changes. The presence of increased mediastinal lymph-node metabolism suggests an extra-pulmonary component.

18F-FDG PET/CT has a potential role to a potential role to phenotype disease and monitor targeted therapy.

Groves, A, Menezes, L, Win, T, Screaton, N, Berovic, M, Endozo, R, Booth, H, Dickson, J, Kayani, I, Ell, P, et al, , Metabolic Insights into the Pathogenesis of Interstitial Lung Disease by Novel 18F-FDG-PET/CT Imaging.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6009517.html