Abstract Archives of the RSNA, 2008
Cancerization of the Lobules in Preinvasive or Early Invasive Breast Carcinoma: Therapy and Outcome Analysis
Presented on December 1, 2008
Presented as part of LL-RO-D: Radiation Oncology and Radiobiology
Federico Laurel Ampil MD, Presenter: Nothing to Disclose
Fleurette W. Abreo MD, Abstract Co-Author: Nothing to Disclose
Roxana Baluna MD, PhD, Abstract Co-Author: Nothing to Disclose
Benjamin Li MD, Abstract Co-Author: Nothing to Disclose
Gary Burton MD, Abstract Co-Author: Nothing to Disclose
Quyen Chu MD, Abstract Co-Author: Nothing to Disclose
Background and Purpose: The equivalent long-term efficacy of breast conservation surgery with radiotherapy to mastectomy for ductal carcinoma-in-situ (DCIS) has not yet been fully documented. Cancerization of the lobules (CL) is often found in cases of DCIS. Because of the infrequent occurrence of CL with preinvasive or early stage carcinoma of the breast, it would be difficult to conduct a randomized trial to evaluate the optimal management of this particular neoplastic condition. The objective of this study is to describe the management and outcome of a series of patients with CL found with DCIS or early invasive carcinoma of the breast.
Methods: Nine hundred forty six patients were diagnosed with breast cancer at a single institution between 1999 and 2006. A retrospective review of pathology reports identified 8 cases of CL associated with DCIS or stage I carcinoma of the breast.
Results: The mean age was 48 (range 31-59) years. CL was seen in conjunction with DCIS (7 patients) or stage I cancer of the breast (1 patient). In half of the women, treatment of the breast lesion was by lumpectomy with radiation and in the other patients, by mastectomy. Among the evaluable individuals, the mean size of the neoplasm was 2.3 (range 0.5-3.2) cm; the tumor was either grade 2 or 3. None of the patients developed locoregional or distant relapse during a follow-up period of up to 90 months. Disease-free survival extended from 8 to 36 months in the organ-preserved treated women and from 17 to 90 months in the mastectomy patient group.
Conclusion: Based on our findings, we believe that breast conservation surgery with radiotherapy seems worthy of consideration in patients with CL seen in connection with DCIS or early cancer of the breast as is mastectomy.
Breast conservation surgery with radiotherapy is a worthy management alternative when mastectomy is not preferred or performed in this particular cohort of patients.
Cancerization of the Lobules in Preinvasive or Early Invasive Breast Carcinoma: Therapy and Outcome Analysis. Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6008601.html