Zhi-gang Yang MD, PhD, Presenter: Nothing to Disclose

Ying-kun Guo MD, Abstract Co-Author: Nothing to Disclose

Xiao-chun Zhang, Abstract Co-Author: Nothing to Disclose

To prospectively assess right ventricular (RV) function and size in patients with mitral regurgitation using retrospectively ECG-gated 64-section multi-detector row CT (64-MDCT) and to compare the results with those of real-time three-dimensional echocardiography (RT3DE) and magnetic resonance (MR) imaging.

42 consecutively patients with mitral regurgitation were enrolled in this study. All patients underwent retrospectively ECG-gated 64-MDCT, RT3DE and MR imaging for assessing the ventricular function. Right ventricular end-diastolic and end-systolic volume (EDV and ESV), stroke volume (SV), ejection fraction (EF) were measured with dedicated cardiac analysis software on 64-MDCT and RT3DE, and compared with values measured on MR imaging which served as the reference standard. Dimension ratios for the RV and left ventricle (LV) were also measured and compared. Difference of functional parameters and size among groups was tested with a parametric analysis of variance test. Agreement between modalities was assessed with Bland and Altman analysis and linear regression.

No significant differences were revealed in calculated right ventricle volumes, EF and RV/LV dimension ratio of three modalities. Both 64-MDCT and RT3DE measurements resulted in high correlation (r>0.92) compared with MR imaging. RV/LV dimension ratio was significantly different among the three groups, according to the degree of mitral regurgitation (p<0.05). The variability in the 64-MDCT measurements was lower than that in MRI and RT3DE values.

The retrospectively ECG-gated 64-MDCT could assess accurately the right ventricular function and size in patients with mitral regurgitation, and measurements correlated and agreed with those obtain with RT3DE and MR imaging. RV/LV dimension ratio measured by 64-MDCT correlated well with the degree of mitral regurgitation.   

The retrospectively ECG-gated 64-MDCT allows a reliable assessment of right ventricular function, which is very important for those patients with mitral regurgitation.  

Yang, Z, Guo, Y, Zhang, X, Quantitative Assessment of Right Ventricular Function and Size in Patients with Mitral Regurgitation Using 64-Section Multi-Detector Row CT: Comparison with Real-time Three-dimensional Echocardiography and Magnetic Resonance Imaging.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6005683.html