Ahmed Abdel Razek, Presenter: Nothing to Disclose

Ahmed Farouk, Abstract Co-Author: Nothing to Disclose

Amani Mousa, Abstract Co-Author: Nothing to Disclose

Nancy Nabil, Abstract Co-Author: Nothing to Disclose

To evaluate the diagnostic value of dynamic contrast enhanced (DCE) MR imaging in characterization of renal tumors.

Prospective study was conducted upon 40 patients (27M, 13F aged 25-72 ys: mean 45ys) with renal tumors. Dynamic fat suppressed gradient-recalled echo MR sequences were obtained before and after the administration of gadopentate dimeglumine every 30 seconds for 5 minutes. The time signal intensity curve (TIC) of the lesion was created. The time to peak, SI peak, enhancement ratio (ER) and washout ratio (WR) were determined from TIC. Perfusion parameters correlated with histopathological results and statistical analysis was done.

The time to peak, SI peak, ER, WR of renal cell carcinoma (RCC) was 49.8±27, 199.1±42, 0.86± 0.6, 37.3±35 respectively and of benign tumors was 75±23, 176.3±84, 1.23±0.7, 29±19. There was significant difference in the ER (P<0.003), time to peak (P<0.02) and insignificant difference in the SI peak (P<0.06) and WR (P<0.07) between malignant and benign renal tumors. There was significant difference in the ER (P<0.03) between conventional and non conventional types of RCC. Selection of 61.2 as a threshold parameter of ER for differentiating RCC from benign tumors has accuracy of 93.6%, sensitivity of 90.6%, specificity of 89.2%, PPV of 88% and NPV of 83%.

Dynamic contrast enhanced perfusion weighted MR imaging of the kidney is a non-invasive imaging modality that can play a role in differentiation of malignant from benign renal tumors and characterization of renal cell carcinoma subtypes.

Dynamic contrast enhanced perfusion weighted MR imaging can be added to routine MR imaging in patients with renal tumors to increased diagnostic accuracy.

Abdel Razek, A, Farouk, A, Mousa, A, Nabil, N, Role of Dynamic Contrast-enhanced Perfusion-weighted MR Imaging in Characterization of Renal Tumors.  Radiological Society of North America 2008 Scientific Assembly and Annual Meeting, February 18 - February 20, 2008 ,Chicago IL. http://archive.rsna.org/2008/6005330.html