Diego San Millan Ruiz, Presenter: Nothing to Disclose

Gerald Martin Wyse MBBCh, Abstract Co-Author: Nothing to Disclose

Aaron Daniel Sasson MD, Abstract Co-Author: Nothing to Disclose

Philippe Gailloud MD, Abstract Co-Author: Nothing to Disclose

Erich Aldrich, Abstract Co-Author: Nothing to Disclose

Robert Wityk, Abstract Co-Author: Nothing to Disclose

Victor Urrutia, Abstract Co-Author: Nothing to Disclose

Beatriz Kohler, Abstract Co-Author: Nothing to Disclose

Amber Jones, Abstract Co-Author: Nothing to Disclose

Kieran J. Murphy MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

256-multislice CT (256CT) is still an experimental prototype.It acquires 0.5mm thickness slices with a craniocaudal coverage of 12.8 cm allowing 3D data acquisition of the entire brain.It offers isotropic spatial resolution similar to 64-slice CT technology with much higher temporal resolution by acquiring 1 imaging volume (V3) in 1s and possibility of performing continuous scanning of a whole brain V3.We present preliminary results of 256CT angiography (256CTA) studies on a 256CT prototype (Toshiba Medical Systems Corporation).

IRB approval and informed consent was obtained for 11 adult out-patients with cerebro-vascular disorders.Perfusion protocol included a localizer scan; a volumetric continuous CT scan initiated 5s after contrast product (CP) infusion, initially at 2s intervals 15 times, and then at 3s intervals 6 times. 45 ml of CP were injected at a rate of 6 ml/s.Total effective dose was 4.5 mSv. Pre-CP, arterial and venous phase images were obtained by a time averaging function where 2 acquired V3 were stacked for each phase.Subtracted images where obtained by subtracting rawdata of the artery and venous phase V3 from pre-contrast V3.Dynamic images were obtained by sequentially adding thinslice subtracted V3 images

excellent quality arterial and venous angiography was obtained in all cases.Venous and arterial contamination on the arterial and venous phases was resolved by using earlier and later acquired V3.The use of the subtracted technique allowed to remove beam hardening artifacts and visualize meningeal arteries and veins, and diploic veins. High resolution 4D dynamic CTA imaging demonstrated the hemodynamics of the intracranial circulation

256CTA covers a craniocaudal distance of 12.8 mm that is sufficient to explore the whole brain in most patients.The high spatial and temporal resolutions of 256CTA coupled with the post-processing acquisition of subtracted and dynamic images render this new technology very promising for studying cerebro-vascular disease

256-slice CT offers new diagnostic possibilities in cerebrovascular disease, its high spatial resolution and unprecedented temporal resolution could make this imaging modality an alternative to DSA

San Millan Ruiz, D, Wyse, G, Sasson, A, Gailloud, P, Aldrich, E, Wityk, R, Urrutia, V, Kohler, B, Jones, A, Murphy, K, et al, , et al, , Preliminary Results with 256 Multislice CT: CT Angiography.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5015995.html