Yonggang Li MD, Presenter: Nothing to Disclose

Liang Guo, Abstract Co-Author: Nothing to Disclose

To investigate the proton magnetic resonance spectroscopy (1H MRS) features of benign and malignant soft tissue tumors in human and to explore its feasibility and application value in the differentiation diagnosis of the soft tissue tumors.

44 cases were divided into three groups. There were 10 cases in nomal group, 14 cases in benign tumor group and 20 casese in malignant tumor group respectively. MRI and in vivo 1.5T 1H MRS were performed on all cases and in vitro 14.1T 1H MRS of fresh samples were studied on 20 cases of soft tissue tumors. The 1H MRS features were analyzed and the correlation study between in vivo 1H MRS findings and that of in vitro 1H MRS was performed. Cho/Cr and Lipid/Cr were calculated on workstation and a statistic test was done.

The 1H MRS in malignant soft tissue tumors showed prominent increased Cho peak and decreased Lipid peak. Among 14 cases of benign soft tissue tumors, only one case revealed significant increased Cho peak and the decreased Lipid peak. The Cho/Cr value in the malignant tumor was larger than in the benign tumor and normal muscle, but the Lipid/Cr value was smaller than in the benign tumor and normal muscle. The differences of Cho/Cr value and Lipid/Cr value between malignant and benign soft tissue tumors were statistically significant(P<0.01). In contrast to benign tumor group, in vitro 1H MRS revealed increased Cho, Lac and mI peak and decreased Lipid and Glc peak in 12 cases of the malignant tumor ,as well as increased Ala， Glu， PC and Gly peak in 8 cases of the malignant tumors. In vivo 1H MRS changes of Cho and Lipid peak in th soft tissue tumors was consistent with in vitro 1H MRS.

The benign and malignant soft tissue tumors in human showed great difference in 1H MRS. In vivo 1H MRS findings demonstrated great consistence with that of in vitro 1H MRS. In vivo 1H MRS has high application value in the differentiation diagnosis of soft tissue tumors.

In vivo 1H MRS has high application value in the differentiation diagnosis of soft tissue tumors.

Li, Y, Guo, L, In Vivo 1.5T and ex Vivo 14.1T 1H MR Spectroscopy Study of Benign and Malignant Soft Tissue Tumors in Human.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5015927.html