Karen Büsing MD, Presenter: Nothing to Disclose

Kristina Kilian, Abstract Co-Author: Nothing to Disclose

Thomas Schaible, Abstract Co-Author: Nothing to Disclose

Wolfgang Neff MD, PhD, Abstract Co-Author: Nothing to Disclose

Claudia Endler, Abstract Co-Author: Nothing to Disclose

Evaluation of prognostic power of the relative fetal lung volume (rFLV) based on prenatal MRI planimetry to determine survival and the necessity of extracorporeal membrane oxygenation (ECMO) therapy in children with congenital diaphragmatic hernia (CDH).

In total, 74 children with CDH underwent MRI FLV measurement within 23 -39 weeks’ gestation. The rFLV was expressed as a percentage of the predicted lung volume calculated with biometric parameters according to 7 different formulas previously described in the literature. Applying the area under the curve, the various rFLVs were investigated for their prognostic accuracy to predict patients’ survival and the need for neonatal ECMO therapy.

All rFLVs were equally suitable to antenatally predict children’s survival but not the need of ECMO therapy. However, for both, neonatal survival and ECMO requirement, the prognostic accuracy of the rFLV was not superior to the absolute FLV measured at antenatal MRI.

The absolute and the relative FLV measured at MR planimetry are equally valuable in predicting mortality but not the necessity of ECMO therapy in children with CDH. Thus, biometric correction of the FLV is unnecessary as it does not improve the prognostic power of MR FLV measurements.

Estimation of patients’ outcome in CDH does not require calculation of the rFLV from biometric measurements as it does not improve the prognostic strength compared to the absolute FLV.

Büsing, K, Kilian, K, Schaible, T, Neff, W, Endler, C, MR Relative Fetal Lung Volume in Congenital Diaphragmatic Hernia: Prediction of Survival and the Need for Extracorporeal Membrane Oxygenation (ECMO) Therapy.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5012866.html