Atsushi Kono MD, Presenter: Nothing to Disclose

Yoshiharu Ohno MD, PhD, Abstract Co-Author: Nothing to Disclose

Munenobu Nogami MD, PhD, Abstract Co-Author: Nothing to Disclose

Hisanobu Koyama MD, Abstract Co-Author: Nothing to Disclose

Daisuke Takenaka MD, Abstract Co-Author: Nothing to Disclose

Yumiko Onishi MD, Abstract Co-Author: Nothing to Disclose

Kazuro Sugimura MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To determine the relationship between glucose uptake of aortic wall on whole-body 18F-fluorodeoxyglucose PET-CT (PET-CT) and severity of arteriosclerosis assessed by aortic wall stiffness in lung cancer patients.

38 consecutive pathologically diagnosed lung cancer patients (25 males and 13 females, mean age, 65.1 yr; range 51-81 yr) underwent PET-CT and phase contrast MRI (PC-MRI). PET-CT examination in each patient was performed on an integrated PET-CT scanner with standard techniques for oncology under fasting state. PC-MRI was performed with a cine 2D sequence using retrospective electrocardiogram triggering, and positioned in a transaxial section perpendicular to the descending aorta at the level of bifurcation of the pulmonary artery. Severity of arteriosclerosis was evaluated by aortic wall stiffness determined by pulse wave velocity (PWV), which was calculated from the slope of the curve of aortic flow plotted against aortic area during systole, from the PC-MRI data. Maximal standardized uptake value (SUVmax) in the ROI outlining the descending aortic wall was determined on transaxial PET-CT images for each patient. To determine the relationship between aortic glucose uptake and severity of arteriosclerosis assessed by aortic wall stiffness, the SUVmax was correlated with PWV by the Pearson’s correlation method. To determine the factors that influenced the aortic glucose uptake, acquisition parameters of PET-CT including plasma glucose levels and patients’ risk factors for arteriosclerosis were evaluated by the multiple regression tests.

SUVmax of aortic wall had a significant and positive correlation with severity of arteriosclerosis assessed by PWV (r= 0.51, p0.05).

Glucose uptake of aortic wall on PET-CT has a potential for non-invasive evaluation of severity of arteriosclerosis in lung cancer patients.

Whole-body FDG PET-CT may have a potential for non-invasive assessment of the severity of arteriosclerosis in lung cancer patients.

Kono, A, Ohno, Y, Nogami, M, Koyama, H, Takenaka, D, Onishi, Y, Sugimura, K, et al, , et al, , Whole Body ¹⁸F-FDG PET-CT: Correlation between Aortic Wall Glucose Uptake and Severity of Arteriosclerosis Assessed by Aortic Wall Stiffness in Lung Cancer Patients.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5012743.html