Hon Soul Kim MD, Presenter: Nothing to Disclose

Myeong-Jin Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

Mi-Suk Park MD, Abstract Co-Author: Nothing to Disclose

Joon Seok Lim MD, Abstract Co-Author: Nothing to Disclose

To identify conditions that might impair the selective hepatobiliary enhancement of gadobenate dimeglumine at delayed images.

Ninety-five patients who underwent gadobenate-enhanced MR imaging were retrospectively analyzed. Delayed hepatobiliary images were obtained between 69 and 282 minutes 201.2 ± 31.7) after the injection of the contrast media. The selective hepatobiliary enhancement at delayed images was categorized into three grades by comparing the subjectively perceived difference of signal intensity (SI) between the liver parenchyma and portal vein of precontrast and delayed images. Three radiologists performed the grading independently. Degree of biliary excretion was also categorized into three grades by comparing SI in common bile duct at precontrast and delayed images. History of liver disease, liver cirrhosis and renal disease, blood urea nitrogen(BUN)/creatinine(Cr), aspartate aminotransferase(AST)/alkaline phosphatase(ALT), bilirubin and alkaline phosphatase (ALP), ascites, splenomegaly and delayed time interval were compared according to the grade of liver enhancement and biliary excretion.

History of liver disease (p=0.002), cirrhosis (p=0.0006), renal disease (p=0.022), presence of ascites (p=0.001) and splenomegaly (p<0.0001), high BUN (p=0.0013), Cr (p=0.003), ALT (p=0.026), bilirubin (p<0.0001), ALP (p<0.0001) were statistically significant factors which impaired the selective hepatobiliary enhancement. Biliary excretion was affected by the presence of liver disease (p<0.0001), cirrhosis (p<0.0001), splenomegaly (p<0.0001), ascites (p=0.0016), high Cr (p=0.013), AST (p=0.029), bilirubin (p<0.0001), ALP (p<0.0001). The timing of delayed images did not influence the degree of selective hepatobiliary enhancement (p=0.53) or biliary excretion (p=0.94).

Selective hepatobiliary enhancement and biliary excretion of gadobenate dimeglumine at delayed images can be impaired in patients suffering from liver or renal disease and/or showing deteriorated profiles of routine liver or renal chemistry tests.

Radiologists should be aware of conditions that might reduce the selective hepatobiliary enhancing effect of gadobenate dimeglumine at delayed images.

Kim, H, Kim, M, Park, M, Lim, J, Potential Conditions Causing Impairment of Selective Hepatobiliary Enhancement of Gadobenate-enhanced Delayed MR Imaging.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5010560.html