Yuan Li, Presenter: Nothing to Disclose

Zgi-gang Yang MD, PhD, Abstract Co-Author: Nothing to Disclose

Tian-wu Chen MD, Abstract Co-Author: Nothing to Disclose

Jian-qun Yu MD, Abstract Co-Author: Nothing to Disclose

Zhen-lin Li MS, Abstract Co-Author: Nothing to Disclose

Jia-yu Sun MS, Abstract Co-Author: Nothing to Disclose

JinHong Wang MD, Abstract Co-Author: Nothing to Disclose

To investigate the feasibility of 64-row MDCT perfusion in evaluating tumor microcirculation of peripheral lung carcinoma and to determine perfusion parameters in different histological types, sizes, metastasis and necrosis.

A total of 94 patients (72M: 22F, mean age 58.2±9.8 years) with primary peripheral lung carcinoma were examined with 64-row MDCT. Tumors (1.8-5.0cm) were confirmed histopathologically, including 55 adenocarcinmas, 27 squamous cell carcinomas, 7 small cell carcinomas, 3 large cell carcinomas and 2 adenosquamous carcinomas. CT perfusion study comprised twelve series of scans over 55sec following a 50 ml intravenous bolus of contrast medium at 6-7 ml/sec. Data was analyzed using commercial software to generate perfusion, peak enhanced (PE), time to peak (TTP), and blood volume (BV). CT perfusion parameters were correlated with histological type, size, metastasis and necrosis. A one-way ANOVA was used to calculated variations in CT perfusion parameters among different categories.

The mean values of perfusion, PE, TTP and BV were 58.9±45.8 (ml/min/ml), 55.2±41.7 (Hu), 35.1±10.7 (Sec) and 31.2±22.2 (ml/100g), respectively. No difference was found in CT perfusion parameters among histological types (p>0.05). Considerable differences with higher perfusion, PE and BV were noted in tumor (≤30mm) than in tumor (＞30mm) (p<0.05). Differences of perfusion, PE and BV between distant metastasis group and relapse-free group were statistically significant (p<0.05). Tumor with necrosis showed lower perfusion, PE and BV as well as longer TTP compare to tumor without necrosis (p<0.05).

64-row MDCT perfusion technique provides feasible method of tumor perfusion. The CT perfusion parameters were associated with tumor size, metastasis and necrosis, likely due to better depiction of heterogeneity for tumor microcirculation in peripheral lung carcinoma.

This study proved the 64-row MDCT could be a feasible paradigm for noninvasive functional imaging and provide more comprehensive patient evaluation serially.

Li, Y, Yang, Z, Chen, T, Yu, J, Li, Z, Sun, J, Wang, J, Perfusion of Peripheral Lung Carcinoma: Evaluation with 64-row MDCT.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5010393.html