ChunYan Zhang, Presenter: Nothing to Disclose

Xiao Ying Wang MD, Abstract Co-Author: Nothing to Disclose

Xue Xiang Jiang MD, Abstract Co-Author: Nothing to Disclose

To evaluate the 3.0T whole body diffusion weighted imaging(WB-DWI) in detection of bone metastases of prostate cancer.

Forty-nine patients diagnosed as prostate cancer by biopsy or surgery were included in this study. All patients received WB-DWI and 99mTc-MDP bone scintigraphy within one month. WB-DWI axial examinations were performed on 3.0T MRI(GE Medical Systems, Signa ExciteTM, HD ) with body coil. Eight stations were used to complete the examination. The parameters of STIR-DWI sequence were as following: TR 5500ms,TE 74.6ms, TI 200ms, FOV 36mm, slice thickness 8mm, spacing 0, matrix 96×96, b value 800mm2/s, MIP images were reconstructed from the data set of axial image. The scanning time for each station was 3minute 2 second, and the total scanning time was 24 minutes 16seconds for each person. All the high signal intensities in the whole body STIR-DWI and radioactivity deposited sites were examined by conventional T1 and fat saturation T2 weighted images to determine the existence of bone metastasis.

Ten of 49 patients were diagnosed as bone metastases. Five patients were found bone metastases exceeding 10 were not included this study. In the remaining 44 patients, 5 patients were detected with 19 bone metastases and 39 patients were found no bone metastases. On WB-DWI, 23 high signal intensity lesions were identified and 17 of the lesions were defined as bone metastases, and the remaining 6 were confirmed as hyperostosis or degenerative cyst. On bone scintigraphy, 59 radioactivity foci were found and 19 of the lesions were confirmed as bone metastases. Overall, the diagnostic sensitivity and specificity of WB-DWI and bone metastases were 89.47 vs. 90.16% and 100% vs.34.43%, respectively. ROC study showed the area of WB-DWI and bone scintigraphy were 89.8% and 67.2%, respectively, which showed statistical significant difference (P=0.008).

WB-DWI may allow us to screen for bone metastasis in the patients of prostate cancers and its diagnostic accuracy may be higher than that of bone scintigraphy.

Whole body diffusion weighted imaging can detect the bone metastases noninvasively, and its accuracy may be higher than that of bone scintigraphy.

Zhang, C, Wang, X, Jiang, X, Detection of Bone Metastases of Prostate Cancer: Comparison between 3.0T Whole Body Diffusion-weighted Imaging and Bone Scintigraphy.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5009088.html