Olivier Seror, Presenter: Nothing to Disclose

Gisèle N'Kontchou MD, Abstract Co-Author: Nothing to Disclose

Corinne Barrucand, Abstract Co-Author: Nothing to Disclose

Martine Assaban MD, Abstract Co-Author: Nothing to Disclose

Mynth Tin-Tin Htar MD, Abstract Co-Author: Nothing to Disclose

Yves Ajavon MD, Abstract Co-Author: Nothing to Disclose

Emmanuelle Coderc MD, Abstract Co-Author: Nothing to Disclose

Nicolas Sellier MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

As the small volume of the left lobe might increase the risk of complication of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), we compared in a retrospective study the tolerance of RFA performed for HCC located in the left vs the right lobes.

Over a 5-year period, 197 consecutive patients with cirrhosis and HCCs located either in the left (n =38) or in the right lobe (n=159) underwent RFA for the treatment of 47 and 198 tumors, respectively. Patient’s characteristics were similar between the two groups excepted a higher percentage of sub capsular tumor in the left lobe: 31% vs 17% (p=0.03)

Treatment of tumors located in the left and right lobes required a mean of 1.05 ± 0.2 and 1.02 ± 0.14 procedures (p=0.34), including a mean of 1.8 ±1.2 and 2 ±1.5 (p=0.43) applications, respectively. Complication rates per procedure performed in the left and right lobes were 7/38 (18%) vs 7/159 (4%) (p=0.01), including capsular haematomas (3 vs 2), transient ascites (1 vs 0), pseudoaneurysms (1 vs 1), portal thrombosis (1 vs 1), liver abscess (0 vs 1), stomach burn (1 vs 0), biliary tract stenosis (1 vs 1), respectively. In multivariate analysis, left lobe OR=3.16 (1.05-9.53) p=0.04, mutifocal HCCs, OR=3.45 (1.14-10.38) p=0.03 sub capsular location OR=3.45 (1.14-10.38) p=0.03 and platelet counts <100 OR=3.45 (1.14-10.38) p=0.03 were independent risk factors of complication.

The left lobe location of HCC is a risk factor of complication after percutaneous RFA.

The higher risk of complication of radiofrequency ablation performed in left liver lobe has to be taken into acount for the treatment decision of HCC.

Seror, O, N'Kontchou, G, Barrucand, C, Assaban, M, Tin-Tin Htar, M, Ajavon, Y, Coderc, E, Sellier, N, et al, , et al, , Is Left Lobe Location of Hepatocellular Carcinoma a Risk Factor of Complications of Radiofrequency Ablation?.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5008866.html