Ko Woon Park MD, Presenter: Nothing to Disclose

Eun Young Ko MD, Abstract Co-Author: Nothing to Disclose

Jung Hee Shin MD, Abstract Co-Author: Nothing to Disclose

Sung Hee Mun MD, Abstract Co-Author: Nothing to Disclose

Suk Jung Kim, Abstract Co-Author: Nothing to Disclose

Boo Kyung Han, Abstract Co-Author: Nothing to Disclose

To analyze the number of samples and specimen characteristics contributing to diagnostic accuracy in performing 11-gauge vacuum-assisted breast biopsy of non-mass calcifications

From January 2004 to December 2006, 320 patients underwent vacuum-assisted breast biopsy for non-mass calcifications. We devided the patients into two groups according to the biopsy results and final diagnoses: accurate diagnosis group and inaccurate diagnosis group. Accurate diagnosis group included the patients who had same histologic results at vacuum-assisted breast biopsy and following surgery, or the patients who showed benign biopsy results and stable calcifications on follow up mammography more than 2 years. Inaccurate diagnosis group included the patients who showed benign biopsy results including ADH but malignant lesions at following surgery, or patients with insufficient calcifications to diagnose the lesion at vacuum-assisted breast biopsy. We compared total number of retrieved calcifications, number of cores containing calcifications, and number of total sample cores on the specimen mammogram between two groups. We evaluated the most important specimen characteristics to get accurate diagnostic result at vacuum-assisted breast biopsy using logistic regression analysis, and accessed cut-off point of specimen number using ROC analysis.

Total 195 patients had surgery after biopsy (n=99) or follow up benign biopsy results with mammography more than 2 years (n=96). As compared with the final diagnosis, 170 cases were diagnosed accurately at vacuum-assisted breast biopsy and 25 cases were inaccurate. Number of cores containing calcifications was most important in obtaining specimen for accurate diagnosis (Odd Ratio 9.8, C.I. 2.013~48.000) (p < .05). The cut-off point of number of cores containing calcifications was 6 (AUC 0.776) (p < .001).

For accurate diagnosis of non-mass calcifications of breast, 6 or more cores containing calcifications should be obtained at 11-gauge vacuum-assisted breast biopsy.

This study suggests a guideline of adequate specimen collection at 11-gauge vacuum-assisted biopsy for accurate diagnosis of non-mass calcifications of breast.

Park, K, Ko, E, Shin, J, Mun, S, Kim, S, Han, B, Vacuum-assisted Breast Biopsy of Non-Mass Calcifications: How Many Calcifications Are Necessary for Diagnosis?.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5008720.html