Pascal Lacombe MD, Abstract Co-Author: Nothing to Disclose

Jean-Pierre Jacques Pelage MD, Presenter: Research grant, BioSphere Medical, Inc Consultant, BioSphere Medical, Inc Research grant, Biocompatibles International plc Consultant, Biocompatibles International plc Research grant, Boston Scientific Corporation Consultant, Boston Scientific Corporation Research grant, Sartorius AG (B. Braun Biotech Inc) Consultant, Sartorius AG (B. Braun Biotech Inc)

Stephen Binsse, Abstract Co-Author: Nothing to Disclose

Sandra Blivet, Abstract Co-Author: Nothing to Disclose

Joelle Roume MD, Abstract Co-Author: Nothing to Disclose

Thierry Chinet MD, Abstract Co-Author: Nothing to Disclose

To evaluate the clinical and morphological results of embolization for diffuse pulmonary arteriovenous malformations (PAVMs)in patients with Rendu Osler disease.

Retrospective analysis of Rendu Osler (hereditary hemorrhagic telangiectasia) patients with diffuse PAVMs (group 1: PAVMs supplied by all subsegmental arteries of at least one lobe and group 2: PAVMs supplied by all segmental arteries of at least one lobe) treated with embolization. Demographics, clinical presentation, number and characteristics of PAVMs, number of procedures and coils were recorded. After embolization, clinical and morphological results were evaluated.

36 (19 and 17 patients in groups 1 and 2, respectively) patients (mean age 36 years) were treated. Neurological events were reported in 44% of patients before embolization. PAVMs were simple or complex in 32 and 4 patients respectively. In two cases a thrombus was found within the aneurysm. The feeding artery was >3mm in 361 PAVMs and ≤ 3mm in 972 PAVMs. A total of 576 PAVMs were embolized in 66 sessions using 1051 coils. Immediate complications included TIA (1 case), suddden deafness (1 case) and proximal migration of coils (2 cases). In two cases the feeding artery could not be catheterized. The mean follow-up after embolization was 44 months. In five patients (14%), recanalization of PAVMs was detected on CT and embolization was repeated. Of interest, a patent foramen ovale (2 cases) and/or liver involvement (5 cases) were present in these patients.

Morphological results of embolization for diffuse PAVMs were similar to those reported for localized PAVMs. In both groups, clinical results were related to the number of lobes involved and, when only one lobe was involved, results were similar to those reported in patients with localized PAVMs.

Morphological results of embolization for diffuse PAVMs seem similar to those reported for localized PAVMs.

Lacombe, P, Pelage, J, Binsse, S, Blivet, S, Roume, J, Chinet, T, Diffuse Pulmonary Arteriovenous Malformations in Rendu-Osler Patients: Long-term Results of Embolization According to the Distribution and Extent of Lung Involvement.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5007509.html