Mika Sano MD, Presenter: Nothing to Disclose

Tomoaki Ichikawa MD, PhD, Abstract Co-Author: Nothing to Disclose

Katsuhiro Sano, Abstract Co-Author: Nothing to Disclose

Utarou Motosugi MD, Abstract Co-Author: Nothing to Disclose

Hironobu Sou, Abstract Co-Author: Nothing to Disclose

Tatsuaki Tsukamoto MD, Abstract Co-Author: Nothing to Disclose

Hiroto Nakajima MD, Abstract Co-Author: Nothing to Disclose

Tsutomu Araki MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To investigate diagnostic performance of super high b-value DWI (SHb DWI) in the visual detection of prostate cancer compared to that of high b-value DWI (Hb DWI).

47 patients with high level of PSA values (4.4-36.9ng/ml) were enrolled in this study. All patients underwent two different kinds of DWI with SHb DWI(b=1000 sec/mm2) and Hb DWI(b=2000 sec/mm2) and T2-weighted MR imaging (T2WI). All MR images were performed using a 1.5T unit with parallel imaging technique. Parameters for DWI were as follows: single-shot SE-EPI with CHESS, non-breathhold, b factor=1000 and 2000 sec/mm2, NEX =4. Transresctal prostatic biopsy for four segmented regions (right and left central zone (CZ) and peripheral zone (PZ)) of the prostate were performed after the MR examination for all patients. Based on their pathological results, 46 segmented regions (CZ:PZ=19:27) in 19 patients proved to have prostate cancers (33 low-grade (Gleason score 6 and 7) and 13 high-grade (Gleason score 8 and more)). All images were independently interpreted by three radiologists without clinical infomation. All readers only visually interpreted all images without ADC measurements. Receiver operation characteristic (ROC) analysis was used to compare the diagnostic performance for detecting prostate cancer among the three MR techniques.

The overall sensitivity and Az value with both SHb DWI (36/46 (78%), 0.90) and Hb DWI (32/46 (76%), 0.89) DWI were significantly higher than those with T2WI (29/46 (63%), 0.76). The sensitivity for detecting the low-grade prostate cancers was significantly higher with SHb DWI (22/33 (63%)) than that with Hb DWI (15/33 (45%)).

super high b-value DWI is more useful than high b-value DWI in the visual detection of prostate cancers, especially in low-grade cancers.

Super high b-value DWI (b=2000 sec/mm2) is more useful than high b-value DWI (b=1000 sec/mm2) in the visual detection of prostate cancers, especially in low-grade cancers.

Sano, M, Ichikawa, T, Sano, K, Motosugi, U, Sou, H, Tsukamoto, T, Nakajima, H, Araki, T, et al, , et al, , Comparison of High b-value and Super High b-value Diffusion-weighted MR Imaging (DWI) in the Visual Detection of Prostate Cancer.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5005239.html