Tatsuyuki Tonan MD, Presenter: Nothing to Disclose

Kiminori Fujimoto MD, PhD, Abstract Co-Author: Nothing to Disclose

Sanae Azuma MD, Abstract Co-Author: Nothing to Disclose

Jun Akiyoshi MD, Abstract Co-Author: Nothing to Disclose

Noriyuki Ono MD, Abstract Co-Author: Nothing to Disclose

Sunao Matsushita MD, Abstract Co-Author: Nothing to Disclose

Masatoshi Ishibashi MD, Abstract Co-Author: Nothing to Disclose

Naofumi Hayabuchi MD, PhD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To analyze the correlations of the conventional indexes of hepatic functional reserve with superparamagnetic iron oxide (SPIO)-MRI and with Technetium-99m-Galactosyl human serum albumin (Tc-99m GSA)-scintigraphy in patients with hepatic dysfunction, whether SPIO-MRI (Kupffer function) can evaluate hepatic functional reserve.

Forty-six patients with hepatic dysfunction who underwent SPIO-enhanced MRI and Tc-99m GSA-scintigraphy were examined retrospectively. In severity of hepatic dysfunction and pathologic findings, 16 patients were classified into chronic hepatitis and 30 patients were liver cirrhosis. On MR imaging, T2*-weighted gradient echo (GRE) images were obtained before and after the administration of SPIO. To assess the effect of SPIO, the percentage hepatic signal-to-noise ratio (SNR) value difference before and after administration of SPIO (= reduction-%SNR) was calculated. On Tc-99m GSA, receptor index (LHL15= liver count divided by the sum of liver and heart counts at 15 minutes) and clearance index (HH15= heart count at 15 minutes divided by the heart count at 3 minutes) were calculated. The correlations of the conventional indexes (biochemical markers and Child-Pugh score) of hepatic functional reserve with reduction-%SNR on and with Tc-99m GSA parameters (HH15, LHL15 and Visual grading score) were analyzed by using Spearman's rank correlation.

The reduction-%SNR was correlated with each conventional index [albumin (Alb), total-bilirubin (T-Bil), prothrombin-time (PT), indocyanine green retention rate at 15 minutes (ICG15) and Child-Pugh score] of hepatic functional reserve as well as Tc-99m GSA parameters (Spearman rank test, P< 0.01, all comparison). The correlation coefficients (Spearman r) between reduction-%SNR and the conventional indexes were as the following: –0.48 for Alb, 0.42 for T-Bil, -0.39 for PT, 0.46 for ICG15 and 0.67 for Child-Pugh score.

SPIO-MRI (= Kupffer function）might be helpful in evaluating the hepatic functional reserve as well as Tc-99m GSA scintigraphy.

The hepatic reduction-%SNR on SPIO-MRI (=Kupffer function）is equal to Technetium-99m-GSA-scintigraphy in evaluating the hepatic functional reserve.

Tonan, T, Fujimoto, K, Azuma, S, Akiyoshi, J, Ono, N, Matsushita, S, Ishibashi, M, Hayabuchi, N, et al, , et al, , Does Kupffer Function Correlate with Hepatic Functional Reserve? Correlation of the Indexes of Hepatic Functional Reserve with Superparamagnetic Iron Oxide MRI and with Technetium-99m-Galactosyl Human Serum Albumin Scintigraphy.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5004838.html