Ettore Squillaci MD, Presenter: Nothing to Disclose

Guglielmo Manenti MD, Abstract Co-Author: Nothing to Disclose

Stefano Mancino MD, Abstract Co-Author: Nothing to Disclose

Roberta Mastrangeli, Abstract Co-Author: Nothing to Disclose

Alberto Bartolucci, Abstract Co-Author: Nothing to Disclose

Giovanni Simonetti MD, Abstract Co-Author: Nothing to Disclose

To explore the possibilities of Diffusion Weighted MR Imaging at 3T (DWI)in the evaluation of normal kidney and in the characterization of different malignant renal lesions.

DWI imaging was performed in 10 normal volunteers and in 28 patients with different know malignant renal tumors. All MR images were obtained at 3T (Achieva, Philips Medical System, Best, The Netherlands) with a phased array body coil. Image quality was tested with different b factors ranging from 0 to 500. The apparent diffusion coefficient (ADC) was calculated on ADC map, obtained at each slice position The ADC was measured in a 9 pixel ROI within the renal tumour.

Mean ADC value in normal renal parenchyma was 2.35±0.31 x 102 mm3/sec, while mean ADC value in malignant renal tumours was 1.69±0.24x102 mm3/sec. In our series there was not a statistically significative difference between ADC values of different histotype (1.73±0.8 clear cell Ca, 1.84±0.4 papillary variant Ca, 1.67±0.9 granular cell Ca, 1.71±0.3 sarcomatoid variant Ca, 1.46 ± 0.6 transitional cell Ca). Mean tumor cellularity was calculated for each lesion as the number of tumour cell nuclei in 10 high-magnification fields in area without regressive phenomena.

3T DWI seem to be a feasible and reliable technique to evaluate normal kidneys and to differentiate malignant renal tumours on the basis of ADC values.

3T DWI seems to be a reliable technique for in vivo tissue characterization of renal tumors on the basis of ADC values.

Squillaci, E, Manenti, G, Mancino, S, Mastrangeli, R, Bartolucci, A, Simonetti, G, Measurement of the Apparent Diffusion Coefficient in Normal Renal Parenchyma and in Malignant Renal Tumours by Diffusion-weighted MR Imaging at 3T.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5003818.html