Mining Chen, Presenter: Nothing to Disclose

Qingyu Zeng, Abstract Co-Author: Nothing to Disclose

RunYi Ban, Abstract Co-Author: Nothing to Disclose

Jian Wei Huo, Abstract Co-Author: Nothing to Disclose

YanSHan Xue, Abstract Co-Author: Nothing to Disclose

Nan Hong MD, Abstract Co-Author: Nothing to Disclose

Xin Chang, Abstract Co-Author: Nothing to Disclose

Meng Wang, Abstract Co-Author: Nothing to Disclose

Gang Deng, Abstract Co-Author: Nothing to Disclose

Jian Xin Liu, Abstract Co-Author: Nothing to Disclose

Wen Jie GAO, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

Τo compare hepatic microvascular parameters in patients with liver cirrhosis with those in healthy volunteers using CT perfusion technique. The relationship of hepatic microvascular parameters and the disease severity in patients with liver cirrhosis was studied initially.

CT perfusion was performed in 29 patients without liver disease (control subjects) and 39 patients with liver cirrhosis who included 22 patients with compensated cirrhosis group and 17 patients with decompensated cirrhosis group proved by clinical and laboratory examinations. CT cine scans were obtained over 50 seconds beginning with the injection of 50ml of contrast agent. Hepatic microvascular parameters: Mean transit time (MTT) and Permeability surface area product (PS) were obtained by perfusion 3 software at GE Advantage Workstation4.2.

Comparing to control subjects group, hepatic microvascular parameters in cirrhotic patients had changed statistically (MTT:12.212±4.6320s vs 15.613±4.1746s,p=0.002 ; PS: 24.964±8.2979 ml/min/100ml vs 18.945±7.2347 ml/min/100ml,p=0.003). The total difference of MTT and PS in control subjects group, compensated cirrhosis group, decompensated cirrhosis group were significant(MTT:15.613±4.1746s, 12.592±4.7518s, 11.721±4.5681s, p=0.010; PS:18.945±7.2347 ml/min/100ml, 22.767±8.3936 ml/min/100ml, 28.735±13.0654 ml/min/100ml，p=0.002). MTT and PS in compensated cirrhotic patients didn't show statistical difference while comparing to other two groups respectively ( p＞0.05). MTT in decompensated cirrhotic patients decreased significantly (p=0.017), PS in decompensated cirrhotic patients increased remarkably when compared to control subjects group (p=0.001).

Hepatic microvascular change in patients with liver cirrhosis could be quantitatively assessed by CT perfusion technique, Hepatic microvascular parameters: MTT and PS measured with CT were significantly altered in decompensated cirrhosis.

Hepatic microvascular parameters may be used to quantitatively assessing hepatic microcirculation correlated with the severity of liver cirrhosis.

Chen, M, Zeng, Q, Ban, R, Huo, J, Xue, Y, Hong, N, Chang, X, Wang, M, Deng, G, Liu, J, GAO, W, et al, , et al, , Hepatic Microvascular Change in Liver Cirrhosis: Clinical Application of CT Perfusion Technique.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5003500.html