Shuangkun Wang MD, Presenter: Nothing to Disclose

Jian-Ping Dai MD, Abstract Co-Author: Nothing to Disclose

Renyou Zhai, Abstract Co-Author: Nothing to Disclose

Lin Ai, Abstract Co-Author: Nothing to Disclose

Jun Ma MD, Abstract Co-Author: Nothing to Disclose

Lei Zhang, Abstract Co-Author: Nothing to Disclose

To evaluate MR Diffusion Tensor Imaging and compare with routine MR imaging in the diagnosis of Diffuse Axonal Injury.

16 adult healthy cats were divided into experimental group (12 cats) and control group (4 cats). Meaney’s model was adopted. Pre-impact and 1, 24 and 48 hours after performed MR routine protocol and DTI. The control group only have scalp cut and cranial bone opened, no brain impact was given. Four symmetric regions of interest (ROI) were placed on the bilateral white matter of cerebral hemisphere to measure the FA, ADC, and signal intensity of T2WI. The brain tissue was obtained for electronic microscopy observation after the last MR scanning.

The pathological examination of the cats from control group did not reveal any lesion. Multiple traumatic axonal injury lesions were found in the deep white matter area of experimental group. There is no significant difference of serial FA, ADC and T2WI signal intensity of control group ( P＞0.05 ), no significant difference of serial T2WI signal intensity and ADC of experimental group ( P＞0.05 ). No significant difference of FA of 1 hour post-injury (P＜0.05) in experimental group, however significant decrease of 24 and 48 hours post-injury ( P＞0.05 ) .

With the detection of lesions which can not be detected by routine MR sequences, diffusion tensor MR imaging is sensitive to white matter injury, it is an ideal tool to diffuse axonal injury.

Diffusion tensor MR imaging is sensitive to white matter injury lesion, may provide some clinical proof for surgeons.

Wang, S, Dai, J, Zhai, R, Ai, L, Ma, J, Zhang, L, Diffusion Tensor Magnetic Resonance Imaging in a Feline Model of Experimental Traumatic Axonal Injury.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5001901.html