Juergen Machann MD, Presenter: Nothing to Disclose

Claus Thamer, Abstract Co-Author: Nothing to Disclose

Gerd Liebig, Abstract Co-Author: Nothing to Disclose

Norbert Stefan, Abstract Co-Author: Nothing to Disclose

Hans-Ulrich Haring, Abstract Co-Author: Nothing to Disclose

Claus Detlef Claussen MD, Abstract Co-Author: Nothing to Disclose

Andreas Fritsche, Abstract Co-Author: Nothing to Disclose

Fritz Schick MD, PhD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

Prevention of obesity and the concomitant disorders as type 2 diabetes and cardiovascular diseases is of major interest, since prevalence of these diseases is increasing worldwide. In order to assess changes of different adipose tissue (AT) compartments during a lifestyle intervention program (TULIP-study) we examined 100 volunteers before (T0), after 6-9 months (T1), and after 2 years of participation (T2) in a combined exercise/dietary program by whole body MRI and MRS of the liver (hepatic lipids, HL).

Up to now, 100 subjects (age 46±11 years, BMI 29.2±5.2 kg/m2) finished the lifestyle intervention and participated in 3 MR examinations for quantification of whole body fat depots (T1-weighted MRI, fast spin echo sequence, TE/TR=12/490ms, semiautomatic separation of adipose and lean tissue) and hepatic lipids (single voxel 1H-MRS, STEAM, TE/TR=10/4000 ms, ratio lipids/water for quantification). Additionally, an oral glucose tolerance test (oGTT) was performed to determine glucose tolerance and insulin sensitivity (IS) and aerobic capacity (VO2proc) was determined by a treadmill test.

At T1/T2, visceral adipose tissue (VAT) was reduced by 15/14%, whereas abdominal subcutaneous fat decreased by 9% after T1 and increased by 1% after T2 compared to T0. Most prominent changes were observed in HL, decreasing by 41% after T1 and 33% after T2. AT of the lower extremities (ATLE) ranging from feet to head of femur decreased by 5%/7% after T1/T2. IS was slightly improved after T1 and T2 and VO2proc was improved by 5/5% after T1/T2.

Our data show that during a lifestyle intervention, consisting of at least 3 hours moderate exercise per week and reduced calorie intake (less than 30% of calories in form of fat), VAT and HL, which play an important role in the pathogenesis of insulin resistance and type 2 diabetes, reveal the clearest changes. The presented data give an overview over the entire cohort without differentiation between responders and non-responders. Supported by the Deutsche Forschungsgemeinschaft (DFG KFO 114/2)

MRI and MRS enable reliable quantification of changes of adipose tissue distribution and ectopic fat depots during lifestyle intervention

Machann, J, Thamer, C, Liebig, G, Stefan, N, Haring, H, Claussen, C, Fritsche, A, Schick, F, et al, , et al, , Quantification of Whole Body Adipose Tissue and Ectopic Fat by MRI and MRS in Subjects at Increased Risk for Type 2 Diabetes Mellitus: An Interventional Lifestyle Study.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5001765.html