Chan Kyo Kim MD, Abstract Co-Author: Nothing to Disclose

Byung Kwan Park MD, Presenter: Nothing to Disclose

Hyun Moo Lee MD, Abstract Co-Author: Nothing to Disclose

Ghee Young Kwon, Abstract Co-Author: Nothing to Disclose

To retrospectively evaluate the imaging quality of diffusion-weighted imaging (DWI), compare the apparent diffusion coefficient (ADC) values for malignant and benign tissues in the peripheral zone (PZ) and transition zone (TZ), and evaluate whether T2-weighted imaging (T2WI) with DWI could improve the prediction of prostate cancer location as compared with T2WI at 3T using a phased-array coil.

Thirty-seven patients underwent T2WI and DWI prior to radical prostatectomy. DWI technique with b=0 and b=1000 sec/mm2 was used. ADC values were measured in benign and malignant tissues in the PZ or TZ. The prediction of prostate cancer location was evaluated in PZ and TZ at T2WI and T2WI with DWI, respectively. Two readers in consensus recorded the presence of prostate cancer at MR imaging and rated the imaging quality of DWI.

For the prediction of 68 prostate tumors, the overall sensitivity and positive predictive value of T2WI with DWI were 84% and 86%, while those of T2WI were 66% and 63%, respectively (P -3mm2/sec, respectively (P <.01). The overall imaging quality in 97% was satisfactory or more.

DWI is a feasible technique that is useful for the differentiation of malignant and benign tissues in the PZ and TZ. Additionally, T2WI with DWI is superior to T2WI alone for the prediction of prostate cancer location.

The results of our study may make an impact on the assessment of men with persistently raised serum PSA levels and negative biopsies – guiding targeting for further biopsy procedures.

Kim, C, Park, B, Lee, H, Kwon, G, Value of Diffusion-weighted Imaging for the Prediction of Prostate Cancer Location at 3T Using a Phased-array Coil: Preliminary Results.  Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, November 25 - November 30, 2007 ,Chicago IL. http://archive.rsna.org/2007/5001582.html