Salvador Villa, Presenter: Nothing to Disclose

Jordi Bruna, Abstract Co-Author: Nothing to Disclose

Navarro Valentí, Abstract Co-Author: Nothing to Disclose

Eugenia Verger, Abstract Co-Author: Nothing to Disclose

Rafael Fuentes-Raspall, Abstract Co-Author: Nothing to Disclose

Anna Lucas, Abstract Co-Author: Nothing to Disclose

To prospectively analyze the improvement of neurological status of patients affected with BM treated with WBI

Patients with BM without indication of more radical approach (open surgery and radiosurgery) were registered. All patients with prognostic RPA classes I, II, and IIIa and IIIb (Gaspar, IJROBP97, Lutterbach, Radiotherapy and Oncology02) were the aim of the study.Inclusion criteria were any age, KPS 50-100, no chemotherapy during WBI, and informed consent. Exclusion criteria were patients with class IIIc (KPS < 70, primary tumor progression, multiple metastases), very bad medical or psico-social conditions, leptomeningeal dissemination or KPS below 50%.Neurological status (NS) was based on modified cerebral stroke scale with the following items: headache, seizures, speech disorders, visual disorders, motor function, brainstem disorder, sensitive disorders, gaiting disorders, and neuro-cognitive function. The use of dexamethasone (DXM) was carefully registered. WBI consisted on total dose of 30 Gy in 10 days. Changes of NS were defined as follows: Clinical improvement was the reduction of 25% of scoring and equal or less dose of DXM; clinical progression was increasing of 25% of scoring or more dose of DXM or both, and clinical stability was defined as the other situations

A total of 197 patients were registered. 81of them (41%) accomplished inclusion criteria, and 51 completed all the follow-up and are the aim of the first analysis.Median age was 60 (34-78)Fulfillment of neurological evaluation is the table: 76.5% of patients were able to be evaluated at the first month. The rest of patients died or were off-study. 15.7% of patients were able to be evaluated at 6 months. At the first visit 64% of intention-to-analyze patients had improved (38.5%) or were stable (25.6%) of their NS. At 6 months 12.5% of intention-to-analyze patients had improved NS

1- 59% of patients were not able for receiving WBI because very bad clinical conditions or other reasons. 2- Just 76.5 % were able to be scored at the first month. 3- The real neurological status improvement or stabilization at the first month was 64%. 4- More patients will be included at time of presentation.Fulfillment of neurological examinations after WBI

Villa, S, Bruna, J, Valentí, N, Verger, E, Fuentes-Raspall, R, Lucas, A, Can Whole Brain Irradiation (WBI) Really Improve Neurological Status of Patients with Brain Metastases (BM)? A Prospective Multicenter Analysis of the Barcelona Glioma Group: First Results.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/8001345.html