Munenobu Nogami MD, Presenter: Nothing to Disclose

Yoshiharu Ohno MD, Abstract Co-Author: Nothing to Disclose

Hisanobu Koyama MD, Abstract Co-Author: Nothing to Disclose

Setsu Sakamoto MD, Abstract Co-Author: Nothing to Disclose

Yuji Nakamoto MD, PhD, Abstract Co-Author: Nothing to Disclose

Kazuro Sugimura MD, Abstract Co-Author: Nothing to Disclose

Daisuke Takenaka MD, Abstract Co-Author: Nothing to Disclose

Masahiko Fujii MD, Abstract Co-Author: Nothing to Disclose

et al, Abstract Co-Author: Nothing to Disclose

To determine the relationship among myocardial glucose uptake, right ventricle (RV) function and pulmonary vascular resistance (PVR) on whole-body 18F-FDG PET/CT in patients with suspected malignancy.

97 consecutive patients (65 males and 32 females, mean age, 67.0 yr; range, 35-84 yr) with suspected malignancy underwent PET, velocity-encoding MR imaging (velocity MRI) and contrast-enhanced CT. All PET examinations were performed on a PET scanner with standard techniques for oncology under fasting state, and co-registered with contrast-enhanced CT. Decreased RV function and increased PVR in the present study were assessed by hemodynamic parameters calculated from velocity MR data (i.e., cardiac index (CI) and acceleration volume (AV) of pulmonary artery). In each subject, SUVmax of right and left ventricle free wall was determined as myocardial uptake by ROI measurement. All subjects were divided visually into two groups according to the myocardial uptake as follows: no-uptake (n=42) and increased-uptake (n=55) groups. To assess the factors that influence myocardial uptake, hemodynamic parameters including CI and AV, acquisition parameters and patients’ backgrounds including plasma glucose levels and fasting periods were compared between two groups by Mann-Whitney’s U test. To determine the relationship among myocardial uptake, RV function and PVR in all subjects and each group, SUVmaxs were correlated with CIs and AVs of pulmonary artery.

There was no significant difference in hemodynamic parameters, acquisition parameters and patients’ backgrounds between two groups. In the increased-uptake group, SUVmax of RV had a negative correlation with CI (r=-0.41, p<0.01) and a negative correlation with AV (r=-0.32, p<0.05).

When visually increased myocardial uptake, SUVmax of right ventricle is useful for assessment of right ventricle function and pulmonary vascular resistance on whole-body FDG PET/CT in patients with suspected malignancy.

Increased SUVmax of RV in case of visually increased myocardial uptake has correlations with decreased RV function and increased PVR, and recommends further investigations of cardiopulmonary disease.

Nogami, M, Ohno, Y, Koyama, H, Sakamoto, S, Nakamoto, Y, Sugimura, K, Takenaka, D, Fujii, M, et al, , Myocardial Glucose Uptake on Whole-body ¹⁸F-FDG PET/CT in Patients with Suspected Malignancy: Correlation with Right Ventricle Function and/or Pulmonary Vascular Resistance.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4436369.html