Kyoung Ah Kim, Presenter: Nothing to Disclose

Jeong Kon Kim MD, Abstract Co-Author: Nothing to Disclose

Kyoung-Sik Cho MD, Abstract Co-Author: Nothing to Disclose

To evaluate the usefulness of apparent diffusion coefficient (ADC) value in the differentiation of metastatic lymph node from non-metastatic lymph node in patients with uterine cervix cancer

In 32 patients with pathologically proved uterine cervical cancer, diffusion-weighted MR imaging by using the free-breathing EPI-STIR sequence (b factor, 0 and 1000 s/mm2; slice thickness, 4 mm) was performed. Diagnosis of metastatic lymph nodes was obtained by surgery (n = 18) or combination positron emission tomography-computed tomography (n = 14). Lymph node location classified into right pelvic, left pelvic and paraaortic areas. ADC values were measured in these three areas and compared between metastatic and non-metastatic lymph nodes. Then, the receiver-operating-characteristics analysis was performed to evaluate the diagnostic performance of ADC value in the differentiation of metastatic lymph nodes from non-metastatic lymph nodes.

Metastasis was confirmed in 32 (33%) of 96 lymph nodes from 20 (63%) of 32 patients. The ADC value was significantly lower in the metastatic lymph nodes (0.77 X 10-3 mm2/s ± 0.20; range, 0.16 – 1.35 X 10-3 mm2/s) than non-metastatic lymph nodes (1.12 X 10-3 mm2/s ± 0.20; range, 0.68 – 1.62 X 10-3 mm2/s) (P < .001). The area under the receiver-operating-characteristics curve for differentiating metastatic lymph nodes from non-metastatic lymph node was 0.921 ± 0.027 (95% CI, 0.848-0.966) in all areas, 0.979 ± 0.024 (95% CI, 0.854 – 0.993) in the right pelvic area, 0.812 ± 0.077 (95% CI, 0.636 – 0.927) in the left pelvic area, and 0.964 ± 0.32 (95% CI, 0.830 – 0.995) in the paraaortic area.

ADC value can be useful in the differentiation of metastatic lymph nodes from non-metastatic lymph nodes in patients with uterine cervix cancer.

ADC value in diffusion weighted image can be useful in not diagnosis but also treatment plan in uterine cervix cancer patients.

Kim, K, Kim, J, Cho, K, Usefulness of Apparent Diffusion Coefficient Value in the Differentiation of Metastatic Lymph Nodes from Non-Metastatic Lymph Nodes in Uterine Cervix Cancer.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4436269.html