Zi-hua Qi PhD, Presenter: Nothing to Disclose

Chuan-fu Li, Abstract Co-Author: Nothing to Disclose

To study the significance of benign and malignant musculoskeletal tumors using multi-functional MR methods including dynamic contrast-enhanced MRI(MR-DCE), diffusion-weighted imaging(DWI), 31P-MRS and 1H-MRS.

Four MR methods were carried out in 33 patients with musculoskeletal tumors. The functional MR parameters were evaluated including time-signal intensity curve(TIC), maximum slope of increase(MSI), maximum slope of decrease(MSD), positive enhancement integral (PEI), signal enhancement ratio(SER), peak time(PT), intracellular pH value (pHi), phosphomonoester (PME), phosphodiester (PDE), phosphocreatine(PCr), inorganic phosphate (Pi)、β-ATP, and the ratios of PCr/PME, PME/NTP and PME/ATP, choline, creatine, apparent diffusion cofficient(ADC) and exponential apparent diffusion cofficient(eADC).

Most lesions with type ⅠorⅡ of TIC were malignant, and using these types as a standard of malignancy, the diagnostic sensitivity, specificity and accuracy was 92.00%, 70.59% and 83.33% respectively. There was a significance of the types of TIC between benign and malignant tumors(PP=0.003). MSI and MSD of metastasis were higher than those of benign tumors (PPP2(P<0.05), while the eADC is opposite.

Combined multi-functional MR methods may get more information and help to improve diagnosis of musculoskeletal tumors.

Multi-functional MR methods may provide more information, and can be recommended to verify diagnostic efficacy.

Qi, Z, Li, C, Application Study of Musculoskeletal Tumors with Combined Multifunctional MR Methods.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4433766.html