Alexia Balanika, Abstract Co-Author: Nothing to Disclose

Themistoklis Nikolaos Spyridopoulos MD, Presenter: Nothing to Disclose

Christos Baltas, Abstract Co-Author: Nothing to Disclose

Alkiviadis Grigorakis, Abstract Co-Author: Nothing to Disclose

Grigorios Skarantavos, Abstract Co-Author: Nothing to Disclose

Athanasios Gouliamos, Abstract Co-Author: Nothing to Disclose

Adrogen-deprivation therapy (ADT) is recommended treatment for patients with non-metastatic prostate carcinoma after prostatectomy. There is a growing concern about the effects of such therapy on the skeleton. The purpose of this pilot study was to establish trabecular and/or cortical osteopenia and to assess geometry impairment, with resultant apparent bone fragility in men with prostate carcinoma receiving ADT therapy.

Eleven patients, 63-72 years old, with nonmetastatic prostate carcinoma after prostatectomy, receiving ADT therapy (at least for 12 months) and fifteen age-matched healthy controls have been evaluated. All subjects were measured on the non-dominant tibia at 4%, 14% and 38% of the tibia length. Volumetric bone mineral density and geometry were assessed with the following parameters: trabecular bone density (TBD) at 4%, cortical bone density (CBD) at 38%, total density (TD) at 4%, cortical area (CoA) at 38%, total area (ToA) at 4% and strength-strain index (SSI) at 14%.

Compared with control subjects, in our patients both trabecular and cortical density were significantly reduced (p<0,01). There was significant difference in the cortical, total area and SSI between patients with prostate carcinoma and ADT therapy and healthy subjects (p<0,01).

The present study indicates that trabecular and cortical osteopenia and geometry impairment occurs in men with prostate carcinoma receiving ADT therapy. Since these alterations result in an increased appendicular fracture risk, preventing treatment would seem appropriate.

ADT in men with nonmetastatic prostate carcinoma leads to accelerated osteoporosis and fracture. pQCT is able to assess noninvasively bone mass and geometry and estimate the appendicular fracture risk

Balanika, A, Spyridopoulos, T, Baltas, C, Grigorakis, A, Skarantavos, G, Gouliamos, A, Volumetric Bone Mineral Density and Geometry Assessed by Peripheral Quantitative Computed Tomography (pQCT) in Men with Prostate Carcinoma Receiving Androgen-Deprivation Therapy: Preliminary Study.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4432429.html