Vladymyr Alekseevich Rogozhyn MD, Abstract Co-Author: Nothing to Disclose

Zina Z Rozhkova PhD, Presenter: Nothing to Disclose

Evgenii G Pedachenko MD, Abstract Co-Author: Nothing to Disclose

Dmitry Maksyuta, Abstract Co-Author: Nothing to Disclose

Our goal is to describe the vertebral body state on the basis of 1H MRS data of the vertebra.

Three groups of subjects are examined by MRI and 1H MRS using 1.5 T Magnetom Vision (SIEMENS). The 1st group (G1) includes 30 healthy volunteers (23 - 64 y). The 2nd group (G2) consists of 23 female patients (42 - 73 y) with vertebral osteoporosis. The 3rd group (G3) consists of 35 patients (36 - 67 y) with vertebral hemangioma. The spectra are recorded with STEAM SVS:TR/TE=3000/20 ms, VOI=1cm3, NS=64; and 2DCSI:TR/TE=3000/20ms, NS=1. In the G1 VOI was placed in L2 vertebral body. In the G2 and G3 VOI was placed in the vertebral body, identified on MR imaging as abnormal.

We consider the signals from water (4.7 ppm) and lipid fractions:CH3(1.0 - 1.1 ppm),(CH2)n (1.5, 2.3 - 2.5, 5.4 ppm). We define the content AM as the peak amplitude and the concentration CM=AM/S, S=ALip+AWat. We describe the state of vertebra in each VOI by the pair T* = { AWat, ALip}, where ALip and AWat are the peak amplitudes of the signals from water and lipids. The configuration 1* ={ AWat> ALip} is observed in the spectra of young volunteers, in the spectra of patients of G3 and in the spectra, overlying the intact tissue of vertebrae of those patients. The configuration 2* = { AWatLip} is observed in the spectra of elderly volunteers and in the spectra of patients of G2. In the G1 and G2 the average values of ALipare equal to 0.793 and 0.639, in G3 in the tumor and in the intact tissue these values are 0.131 and 0.178, respectively.

The quantitative classification of the state of vertebra according to the dyad spectral configurations allows us to differentiate vertebrae pathologies.

Proton MRS is very useful method in the evaluation of osteoporosis and easy add-on method to the routine MRI for classification of hemangioms.

Rogozhyn, V, Rozhkova, Z, Pedachenko, E, Maksyuta, D, Classification of the State of Vertebra Body Using ¹H MRS.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4431426.html