Fei Yuan MD, Presenter: Nothing to Disclose

Ji Qi MD, Abstract Co-Author: Nothing to Disclose

Miaomiao Long MA, Abstract Co-Author: Nothing to Disclose

Yinshe Liu, Abstract Co-Author: Nothing to Disclose

Bin Yuan, Abstract Co-Author: Nothing to Disclose

To investigate the abnormality of diffusion tensor imaging of white matter(WM) in SIVD and the relationship between the DTI paremeters in different regions and cognitive status and other clinical findings.

The research was performed in 34 SIVD patients and 26 age-matched nondemented older adults. All patients and controls received DTI examination . For each individual, regional FA(fractional anisotropy), PA(principal anisotropy, FApri) and mean ADC measures were estimated from prefrontal white matter(WM), deep frontal WM, inferior frontal WM, medial orbitofrontal WM, anterior and posterior periventricular WM, temporal lobe WM, parietal lobe WM and occipital lobe WM and within hyperintensities identified on T2WI and outside these lesions.

PA value of left prefrontal WM was greater than right side in control group. In SIVD group, FA and PA value of right medial orbitofrontal WM, posterior periventricular WM and occipital lobe WM were significantly greater than left side. FA and PA value of left inferior frontal WM was significantly greater than right side. In addition to the areas of T2-weighted MR imaging hyperintense and perilesions areas, FA, PA and mean ADC differed significantly between SIVD group and control group in prefrontal white matter(WM), deep frontal WM, inferior frontal WM, medial orbitofrontal WM, anterior periventricular WM. On the other hands, mean ADC values of temporal lobe WM, parietal lobe WM and occipital lobe WM significantly increased in SIVD group compared with control group. Significant positive correlation was found between MMSE and FA of prefrontal WM , FA of temporal lobe WM showed positive correlation with degrees of education.

These results indicate that WM alterations are variable throughout the brain and regionally selective damages in SIVD measured by FA ,PA and mean ADC value，which fibers populations within anterior brain regions are most vulnerable to small vascular disease injury and posterior region relatively remain integrality . DTI appears to be a promising technique for white matter damage differences in SIVD.

These results are helpful for early and accurate prevention and treatment of SIVD.

Yuan, F, Qi, J, Long, M, Liu, Y, Yuan, B, Diffusion Tensor Imaging Study in Subcortical Ischemic Vascular Dementia.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4430815.html