Young Hoon Ryu MD, Presenter: Nothing to Disclose

Jong Doo Lee, Abstract Co-Author: Nothing to Disclose

Mijin Yun MD, Abstract Co-Author: Nothing to Disclose

Tae Hoon Kim, Abstract Co-Author: Nothing to Disclose

Sang Jin Kim MD, Abstract Co-Author: Nothing to Disclose

Hyung Joong Kim MD,PhD, Abstract Co-Author: Nothing to Disclose

Hypereosinophilic syndrome (HES) is an infiltrative disease of eosinophils affecting multiple organs including the lung. F-2-fluoro-2-deoxyglucose(F-18 FDG) may accumulate at sites of inflammation or infection, making interpretation of whole body PET scan difficult in patients with cancer. This study was to evaluate the PET findings of HES with lung involvement and to find out differential PET features between lung malignancy and HES with lung involvement.

F-18 FDG PET and low dose chest CT scan was performed for screening of lung cancer. Eight patients who showed ground-glass attenuation (GGA) and consolidation on chest CT scan with peripheral blood eosinophilia were included in this study. The patients with history of parasite infection were excluded. CT features and FDG PET findings were meticulously evaluated for distribution of GGA and consolidations and nodules on CT scan and mean and maximal SUV of abnormalities depicted on PET scan. In eight patients, follow-up chest CT scan and F-18 FDG PET scan were done one or two weeks after initial study.

F-18 FDG PET scan identified metabolically active lesions in seven out of eight patients. Maximal SUV was ranged from 2.8 to 10.6 and mean SUV was ranged from 2.2 to 7.3. Remaining one patient has maximal SUV of 1.3. On follow-up F-18 FDG PET scan taken on from one week to one month later showed decreased degree of FDG uptakes or migration of previously noted abnormal FDG uptakes.

Lung involvement in the HES might be identified as abnormal F-18 FDG uptake foci on F-18 FDG PET scan simulating lung cancer. Follow-up F-18 FDG PET and CT scan would be of help for the differentiation between lung cancer and HES with lung involvement.

Lung involvement in the HES may show abnormal high uptakes on F-18 FDG PET scan simulating lung cancer. Follow-up F-18 FDG PET and CT scan would be helpful for the differentiation.

Ryu, Y, Lee, J, Yun, M, Kim, T, Kim, S, Kim, H, False Positive F-18 FDG PET Scan in Patients with Pulmonary Involvement in the Hypereosinophilic Syndrome Simulating Lung Cancer.  Radiological Society of North America 2006 Scientific Assembly and Annual Meeting, November 26 - December 1, 2006 ,Chicago IL. http://archive.rsna.org/2006/4429442.html